0	10	Regulation	Regulation	NNP
11	13	of	of	IN
14	22	NF-kappa	NF-kappa	NNP
23	24	B	B	NNP
24	25	,	,	,
26	30	AP-1	AP-1	NNP
30	31	,	,	,
32	36	NFAT	NFAT	NNP
36	37	,	,	,
38	41	and	and	CC
42	47	STAT1	stat1	NN
48	55	nuclear	nuclear	JJ
56	62	import	import	NN
63	65	in	in	IN
66	67	T	t	NN
68	79	lymphocytes	lymphocyte	NNS
80	82	by	by	IN
83	94	noninvasive	noninvasive	JJ
95	103	delivery	delivery	NN
104	106	of	of	IN
107	114	peptide	peptide	NN
115	123	carrying	carry	VBG
124	127	the	the	DT
128	135	nuclear	nuclear	JJ
136	148	localization	localization	NN
149	157	sequence	sequence	NN
158	160	of	of	IN
161	169	NF-kappa	NF-kappa	NNP
170	171	B	B	NNP
172	175	p50	p50	NN
175	176	.	.	.

178	188	Activation	Activation	NNP
189	191	of	of	IN
192	193	T	t	NN
194	205	lymphocytes	lymphocyte	NNS
206	208	by	by	IN
209	212	Ags	ag	NNS
213	215	or	or	CC
216	225	cytokines	cytokine	NNS
226	233	results	result	VBZ
234	236	in	in	IN
237	250	translocation	translocation	NN
251	253	of	of	IN
254	257	the	the	DT
258	271	transcription	transcription	NN
272	279	factors	factor	NNS
280	288	NF-kappa	NF-kappa	NNP
289	290	B	B	NNP
290	291	,	,	,
292	296	AP-1	AP-1	NNP
296	297	,	,	,
298	302	NFAT	NFAT	NNP
302	303	,	,	,
304	307	and	and	CC
308	312	STAT	STAT	NNP
313	317	from	from	IN
318	321	the	the	DT
322	331	cytoplasm	cytoplasm	NN
332	336	into	into	IN
337	340	the	the	DT
341	348	nucleus	nucleus	NN
348	349	.	.	.

350	353	The	the	DT
354	359	first	first	JJ
360	364	step	step	NN
365	367	in	in	IN
368	371	the	the	DT
372	379	nuclear	nuclear	JJ
380	386	import	import	NN
387	394	process	process	NN
395	397	is	be	VBZ
398	409	recognition	recognition	NN
410	412	of	of	IN
413	414	a	a	DT
415	422	nuclear	nuclear	JJ
423	435	localization	localization	NN
436	444	sequence	sequence	NN
445	446	(	(	(
446	449	NLS	nls	NN
449	450	)	)	)
451	457	within	within	IN
458	461	the	the	DT
462	473	karyophilic	karyophilic	JJ
474	481	protein	protein	NN
482	484	by	by	IN
485	486	a	a	DT
487	498	cytoplasmic	cytoplasmic	JJ
499	507	receptor	receptor	NN
508	512	such	such	JJ
513	515	as	as	IN
516	519	the	the	DT
520	528	importin	importin	NN
529	530	(	(	(
530	548	karyopherin)-alpha	karyopherin)-alpha	NN
549	556	subunit	subunit	NN
556	557	.	.	.

558	561	The	the	DT
562	566	NLSs	NLS	NNP
567	569	of	of	IN
570	578	NF-kappa	NF-kappa	NNP
579	580	B	B	NNP
580	581	,	,	,
582	586	AP-1	ap-1	NN
586	587	,	,	,
588	591	and	and	CC
592	596	NFAT	nfat	NN
597	603	differ	differ	NN
604	607	and	and	CC
608	611	the	the	DT
612	615	NLS	nls	NN
616	618	of	of	IN
619	624	STAT1	STAT1	NNP
625	628	has	have	VBZ
629	632	not	not	RB
633	636	yet	yet	RB
637	641	been	be	VBN
642	652	identified	identify	VBN
652	653	.	.	.

654	660	Herein	herein	RB
661	663	we	we	PRP
664	675	demonstrate	demonstrate	VBP
676	680	that	that	IN
681	684	the	the	DT
685	694	inducible	inducible	JJ
695	702	nuclear	nuclear	JJ
703	709	import	import	NN
710	712	of	of	IN
713	721	NF-kappa	NF-kappa	NNP
722	723	B	B	NNP
723	724	,	,	,
725	729	AP-1	AP-1	NNP
729	730	,	,	,
731	735	NFAT	NFAT	NNP
735	736	,	,	,
737	740	and	and	CC
741	746	STAT1	STAT1	NNP
747	749	in	in	IN
750	756	Jurkat	Jurkat	NNP
757	758	T	t	NN
759	770	lymphocytes	lymphocyte	NNS
771	773	is	be	VBZ
774	787	significantly	significantly	RB
788	797	inhibited	inhibit	VBN
798	800	by	by	IN
801	802	a	a	DT
803	817	cell-permeable	cell-permeable	JJ
818	825	peptide	peptide	NN
826	834	carrying	carry	VBG
835	838	the	the	DT
839	842	NLS	nls	NN
843	845	of	of	IN
846	849	the	the	DT
850	858	NF-kappa	NF-kappa	NNP
859	860	B	B	NNP
861	864	p50	p50	NN
865	872	subunit	subunit	NN
872	873	.	.	.

874	877	NLS	NLS	NNP
878	894	peptide-mediated	peptide-mediated	JJ
895	905	disruption	disruption	NN
906	908	of	of	IN
909	912	the	the	DT
913	920	nuclear	nuclear	JJ
921	927	import	import	NN
928	930	of	of	IN
931	936	these	these	DT
937	950	transcription	transcription	NN
951	958	factors	factor	NNS
959	966	results	result	VBZ
967	969	in	in	IN
970	980	inhibition	inhibition	NN
981	983	of	of	IN
984	985	I	i	NN
986	991	kappa	kappa	NN
992	993	B	B	NNP
994	999	alpha	alpha	NN
1000	1003	and	and	CC
1004	1008	IL-2	il-2	NN
1009	1013	gene	gene	NN
1014	1024	expression	expression	NN
1024	1025	,	,	,
1026	1035	processes	process	NNS
1036	1045	dependent	dependent	JJ
1046	1048	on	on	IN
1049	1057	NF-kappa	NF-kappa	NNP
1058	1059	B	B	NNP
1060	1062	or	or	CC
1063	1066	the	the	DT
1067	1078	combination	combination	NN
1079	1081	of	of	IN
1082	1090	NF-kappa	NF-kappa	NNP
1091	1092	B	B	NNP
1092	1093	,	,	,
1094	1098	AP-1	ap-1	NN
1098	1099	,	,	,
1100	1103	and	and	CC
1104	1108	NFAT	NFAT	NNP
1108	1109	.	.	.

1110	1117	Further	further	RB
1117	1118	,	,	,
1119	1121	we	we	PRP
1122	1126	show	show	VBP
1127	1131	that	that	IN
1132	1142	inhibitory	inhibitory	JJ
1143	1146	NLS	nls	NN
1147	1154	peptide	peptide	NN
1155	1164	interacts	interact	VBZ
1165	1167	in	in	FW
1168	1173	vitro	vitro	FW
1174	1178	with	with	IN
1179	1180	a	a	DT
1181	1192	cytoplasmic	cytoplasmic	JJ
1193	1196	NLS	NLS	NNP
1197	1205	receptor	receptor	NN
1206	1213	complex	complex	NN
1214	1223	comprised	comprise	VBN
1224	1226	of	of	IN
1227	1230	the	the	DT
1231	1244	Rch1/importin	Rch1/importin	NNP
1245	1246	(	(	(
1246	1263	karyopherin)-beta	karyopherin)-beta	NN
1264	1275	heterodimer	heterodimer	NN
1276	1285	expressed	express	VBN
1286	1288	in	in	IN
1289	1295	Jurkat	Jurkat	NNP
1296	1297	T	t	NN
1298	1303	cells	cell	NNS
1303	1304	.	.	.

1305	1310	Taken	take	VBN
1311	1319	together	together	RB
1319	1320	,	,	,
1321	1326	these	these	DT
1327	1331	data	datum	NNS
1332	1340	indicate	indicate	VBP
1341	1345	that	that	IN
1346	1349	the	the	DT
1350	1359	inducible	inducible	JJ
1360	1367	nuclear	nuclear	JJ
1368	1374	import	import	NN
1375	1377	of	of	IN
1378	1386	NF-kappa	NF-kappa	NNP
1387	1388	B	B	NNP
1388	1389	,	,	,
1390	1394	AP-1	AP-1	NNP
1394	1395	,	,	,
1396	1400	NFAT	NFAT	NNP
1400	1401	,	,	,
1402	1405	and	and	CC
1406	1411	STAT1	STAT1	NNP
1412	1414	in	in	IN
1415	1421	Jurkat	Jurkat	NNP
1422	1423	T	t	NN
1424	1429	cells	cell	NNS
1430	1433	can	can	MD
1434	1436	be	be	VB
1437	1446	regulated	regulate	VBN
1447	1449	by	by	IN
1450	1453	NLS	nls	NN
1454	1461	peptide	peptide	NN
1462	1471	delivered	deliver	VBN
1472	1485	noninvasively	noninvasively	RB
1486	1488	to	to	TO
1489	1492	the	the	DT
1493	1502	cytoplasm	cytoplasm	NN
1503	1505	of	of	IN
1506	1512	Jurkat	Jurkat	NNP
1513	1514	T	t	NN
1515	1520	cells	cell	NNS
1521	1523	to	to	TO
1524	1530	target	target	VB
1531	1538	members	member	NNS
1539	1541	of	of	IN
1542	1545	the	the	DT
1546	1554	importin	importin	NN
1555	1556	(	(	(
1556	1574	karyopherin)-alpha	karyopherin)-alpha	NN
1575	1579	beta	beta	NN
1580	1583	NLS	nls	NN
1584	1592	receptor	receptor	NN
1593	1600	complex	complex	NN
1600	1601	.	.	.