0 11 Involvement involvement NN 12 14 of of IN 15 23 tyrosine tyrosine NN 24 39 phosphorylation phosphorylation NN 40 42 in in IN 43 54 endothelial endothelial JJ 55 63 adhesion adhesion NN 64 72 molecule molecule NN 73 82 induction induction NN 82 83 . . . 85 94 Induction Induction NNP 95 97 of of IN 98 109 endothelial endothelial JJ 110 118 adhesion adhesion NN 119 128 molecules molecule NNS 129 131 by by IN 132 135 the the DT 136 144 cytokine cytokine NN 145 150 tumor tumor NN 151 159 necrosis necrosis NN 160 172 factor-alpha factor-alpha NN 173 174 ( ( ( 174 177 TNF TNF NNP 177 178 ) ) ) 179 182 can can MD 183 188 occur occur VB 189 202 independently independently RB 203 205 of of IN 206 213 protein protein NN 214 220 kinase kinase NNP 221 222 C C NNP 223 226 and and CC 227 237 activation activation NN 238 240 of of IN 241 242 a a DT 243 250 protein protein NN 251 259 tyrosine tyrosine NN 260 266 kinase kinase NNP 267 268 ( ( ( 268 271 PTK PTK NNP 271 272 ) ) ) 273 276 has have VBZ 277 285 recently recently RB 286 290 been be VBN 291 301 implicated implicate VBN 302 304 in in IN 305 308 the the DT 309 321 upregulation upregulation NN 322 324 of of IN 325 333 vascular vascular JJ 334 338 cell cell NN 339 347 adhesion adhesion NN 348 356 molecule molecule NN 357 358 1 1 CD 359 360 ( ( ( 360 366 VCAM-1 vcam-1 NN 366 367 ) ) ) 368 370 by by IN 371 384 interleukin-4 interleukin-4 NN 385 386 ( ( ( 386 390 IL-4 il-4 NN 390 391 ) ) ) 392 394 on on IN 395 406 endothelial endothelial JJ 407 412 cells cell NNS 412 413 . . . 414 416 We we PRP 417 428 demonstrate demonstrate VBP 429 433 that that IN 434 437 the the DT 438 441 PTK PTK NNP 442 452 inhibitors inhibitor NNS 453 463 herbimycin herbimycin NN 464 465 A a NN 466 468 or or CC 469 478 genistein genistein NN 479 487 suppress suppress VBP 488 497 induction induction NN 498 500 of of IN 501 512 endothelial endothelial JJ 513 519 VCAM-1 vcam-1 NN 520 523 and and CC 524 534 E-selectin E-selectin NNP 534 535 , , , 536 538 as as RB 539 543 well well RB 544 546 as as IN 547 557 subsequent subsequent JJ 558 567 monocytic monocytic JJ 568 572 cell cell NN 573 581 adhesion adhesion NN 582 584 to to TO 585 596 endothelial endothelial JJ 597 602 cells cell NNS 603 613 stimulated stimulate VBN 614 616 by by IN 617 620 TNF TNF NNP 620 621 . . . 622 632 Inhibition Inhibition NNP 633 640 studies study NNS 641 649 indicate indicate VBP 650 654 that that IN 655 663 specific specific JJ 664 672 tyrosine tyrosine NN 673 688 phosphorylation phosphorylation NN 689 698 following follow VBG 699 702 PTK PTK NNP 703 713 activation activation NN 714 716 is be VBZ 717 725 involved involve VBN 726 728 in in IN 729 732 the the DT 733 745 mobilization mobilization NN 746 748 of of IN 749 752 the the DT 753 766 transcription transcription NN 767 773 factor factor NN 773 774 , , , 775 782 nuclear nuclear JJ 783 789 factor factor NN 790 795 kappa kappa NN 796 797 B B NNP 797 798 , , , 799 802 and and CC 803 809 VCAM-1 vcam-1 NN 810 814 mRNA mrna NN 815 825 expression expression NN 825 826 . . . 827 831 This this DT 832 835 may may MD 836 840 have have VB 841 853 implications implication NNS 854 857 for for IN 858 876 pathophysiological pathophysiological JJ 877 887 conditions condition NNS 888 892 that that WDT 893 900 involve involve VBP 901 904 the the DT 905 917 upregulation upregulation NN 918 920 of of IN 921 926 these these DT 927 936 molecules molecule NNS 937 938 ( ( ( 938 942 e.g. e.g. FW 943 955 inflammation inflammation NN 956 959 and and CC 960 975 atherosclerosis atherosclerosis NN 975 976 ) ) ) 976 977 . . .