0	10	Expression	expression	NN
11	17	levels	level	NNS
18	20	of	of	IN
21	24	the	the	DT
25	36	thyrotropin	thyrotropin	NN
37	45	receptor	receptor	NN
46	50	gene	gene	NN
51	53	in	in	IN
54	64	autoimmune	autoimmune	JJ
65	72	thyroid	thyroid	NN
73	80	disease	disease	NN
80	81	:	:	:
82	94	coregulation	coregulation	NN
95	99	with	with	IN
100	110	parameters	parameter	NNS
111	113	of	of	IN
114	121	thyroid	thyroid	NN
122	130	function	function	NN
131	134	and	and	CC
135	142	inverse	inverse	JJ
143	151	relation	relation	NN
152	154	to	to	TO
155	160	major	major	JJ
161	179	histocompatibility	histocompatibility	NN
180	187	complex	complex	NN
188	195	classes	class	NNS
196	197	I	i	CD
198	201	and	and	CC
202	204	II	ii	CD
204	205	.	.	.

207	212	Using	use	VBG
213	214	a	a	DT
215	220	human	human	JJ
221	224	TSH	tsh	NN
225	233	receptor	receptor	NN
234	235	(	(	(
235	240	TSH-R	TSH-R	NNP
240	241	)	)	)
242	246	cDNA	cdna	NN
247	252	probe	probe	NN
252	253	,	,	,
254	256	we	we	PRP
257	269	investigated	investigate	VBD
270	275	TSH-R	tsh-r	NN
276	286	transcript	transcript	NN
287	293	levels	level	NNS
294	296	in	in	IN
297	299	13	13	CD
300	305	human	human	JJ
306	313	thyroid	thyroid	NN
314	323	fragments	fragment	NNS
324	326	by	by	IN
327	335	Northern	northern	NN
336	340	blot	blot	NN
341	349	analysis	analysis	NN
349	350	;	;	:
351	352	7	7	CD
353	359	Graves	Graves	NNP
359	360	’	'	POS
361	368	disease	disease	NN
368	369	,	,	,
370	371	2	2	CD
372	381	Hashimoto	Hashimoto	NNP
381	383	’s	's	POS
384	391	disease	disease	NN
391	392	,	,	,
393	394	3	3	CD
395	402	endemic	endemic	JJ
403	409	goiter	goiter	NN
409	410	,	,	,
411	414	and	and	CC
415	416	1	1	CD
417	424	healthy	healthy	JJ
425	432	thyroid	thyroid	NN
433	438	gland	gland	NN
439	443	were	be	VBD
444	451	studied	study	VBN
451	452	.	.	.

453	458	TSH-R	TSH-R	NNP
459	469	expression	expression	NN
470	476	levels	level	NNS
477	481	were	be	VBD
482	490	variable	variable	JJ
490	491	,	,	,
492	495	but	but	CC
496	505	displayed	display	VBD
506	507	a	a	DT
508	513	close	close	JJ
514	525	correlation	correlation	NN
526	528	to	to	TO
529	532	the	the	DT
533	543	expression	expression	NN
544	546	of	of	IN
547	554	thyroid	thyroid	NN
555	565	peroxidase	peroxidase	NN
566	567	(	(	(
567	568	r	r	NN
569	570	=	=	SYM
571	576	0.703	0.703	CD
576	577	;	;	:
578	579	P	p	NN
580	581	<	<	SYM
582	586	0.05	0.05	CD
586	587	)	)	)
587	588	,	,	,
589	602	thyroglobulin	thyroglobulin	NN
603	604	(	(	(
604	605	r	r	NN
606	607	=	=	SYM
608	613	0.817	0.817	CD
613	614	;	;	:
615	616	P	p	NN
617	618	<	<	SYM
619	623	0.01	0.01	CD
623	624	)	)	)
624	625	,	,	,
626	629	and	and	CC
630	633	the	the	DT
634	641	nuclear	nuclear	JJ
642	650	oncogene	oncogene	NN
651	656	c-fos	c-fos	NN
657	658	(	(	(
658	659	r	r	NN
660	661	=	=	SYM
662	667	0.935	0.935	CD
667	668	;	;	:
669	670	P	p	NN
671	672	<	<	SYM
673	678	0.001	0.001	CD
678	679	)	)	)
679	680	,	,	,
681	684	but	but	CC
685	688	not	not	RB
689	694	c-myc	c-myc	NN
694	695	.	.	.

696	703	Overall	overall	RB
703	704	,	,	,
705	710	TSH-R	TSH-R	NNP
711	721	transcript	transcript	NN
722	728	levels	level	NNS
729	733	were	be	VBD
734	737	low	low	JJ
738	740	or	or	CC
741	747	absent	absent	JJ
748	750	in	in	IN
751	756	those	those	DT
757	765	thyroids	thyroid	NNS
766	768	in	in	IN
769	774	which	which	WDT
775	785	expression	expression	NN
786	788	of	of	IN
789	792	the	the	DT
793	798	major	major	JJ
799	817	histocompatibility	histocompatibility	NN
818	825	complex	complex	NN
826	831	class	class	NN
832	833	I	i	CD
834	836	or	or	CC
837	839	II	ii	CD
840	841	(	(	(
841	844	MHC	MHC	NNP
845	846	I	i	CD
847	849	or	or	CC
850	852	II	ii	CD
852	853	)	)	)
854	857	was	be	VBD
858	862	high	high	JJ
862	863	,	,	,
864	868	thus	thus	RB
869	881	establishing	establish	VBG
882	884	an	an	DT
885	892	inverse	inverse	JJ
893	901	relation	relation	NN
902	903	(	(	(
903	906	MHC	MHC	NNP
907	908	I	i	NN
908	909	,	,	,
910	911	r	r	NN
912	913	=	=	SYM
914	920	-0.791	-0.791	CD
920	921	;	;	:
922	923	P	p	NN
924	925	<	<	SYM
926	930	0.01	0.01	CD
930	931	;	;	:
932	935	MHC	MHC	NNP
936	938	II	ii	CD
938	939	,	,	,
940	941	r	r	NN
942	943	=	=	SYM
944	950	-0.784	-0.784	CD
950	951	;	;	:
952	953	P	p	NN
954	955	<	<	SYM
956	960	0.01	0.01	CD
960	961	)	)	)
961	962	.	.	.

963	965	In	in	FW
966	970	situ	situ	FW
971	984	hybridization	hybridization	NN
985	991	showed	show	VBD
992	996	that	that	IN
997	1002	apart	apart	RB
1003	1007	from	from	IN
1008	1019	lymphocytes	lymphocyte	NNS
1019	1020	,	,	,
1021	1028	thyroid	thyroid	JJ
1029	1034	cells	cell	NNS
1035	1045	themselves	themselves	PRP
1046	1050	were	be	VBD
1051	1054	the	the	DT
1055	1061	source	source	NN
1062	1064	of	of	IN
1065	1068	MHC	MHC	NNP
1069	1071	II	ii	CD
1072	1084	transcripts.	transcripts.	NN
1085	1101	gamma-Interferon	gamma-interferon	NN
1102	1112	expression	expression	NN
1113	1116	was	be	VBD
1117	1121	only	only	RB
1122	1132	detectable	detectable	JJ
1133	1135	in	in	IN
1136	1137	1	1	CD
1138	1147	Hashimoto	Hashimoto	NNP
1147	1149	’s	's	POS
1150	1156	goiter	goiter	NN
1156	1157	.	.	.

1158	1161	Our	our	PRP$
1162	1170	findings	finding	NNS
1171	1178	suggest	suggest	VBP
1179	1183	that	that	IN
1184	1188	next	next	JJ
1189	1191	to	to	TO
1192	1202	lymphocyte	lymphocyte	NN
1203	1215	infiltration	infiltration	NN
1215	1216	,	,	,
1217	1223	active	active	JJ
1224	1234	regulatory	regulatory	JJ
1235	1241	events	event	NNS
1242	1244	in	in	IN
1245	1248	the	the	DT
1249	1258	thyrocyte	thyrocyte	NN
1259	1262	are	be	VBP
1263	1274	responsible	responsible	JJ
1275	1278	for	for	IN
1279	1282	the	the	DT
1283	1290	inverse	inverse	JJ
1291	1299	relation	relation	NN
1300	1307	between	between	IN
1308	1318	functional	functional	JJ
1319	1329	parameters	parameter	NNS
1330	1331	(	(	(
1331	1336	TSH-R	TSH-R	NNP
1336	1337	,	,	,
1338	1345	thyroid	thyroid	NN
1346	1356	peroxidase	peroxidase	NN
1356	1357	,	,	,
1358	1371	thyroglobulin	thyroglobulin	NN
1371	1372	,	,	,
1373	1376	and	and	CC
1377	1382	c-fos	c-fos	NN
1382	1383	)	)	)
1384	1387	and	and	CC
1388	1401	immunological	immunological	JJ
1402	1409	markers	marker	NNS
1410	1411	(	(	(
1411	1414	MHC	MHC	NNP
1415	1416	I	i	CD
1417	1420	and	and	CC
1421	1423	II	ii	CD
1423	1424	)	)	)
1424	1425	.	.	.