0 11 Stimulation stimulation NN 12 14 of of IN 15 28 interleukin-1 interleukin-1 NN 29 34 alpha alpha NN 35 38 and and CC 39 52 interleukin-1 interleukin-1 NN 53 57 beta beta NN 58 68 production production NN 69 71 in in IN 72 77 human human JJ 78 87 monocytes monocyte NNS 88 90 by by IN 91 98 protein protein NN 99 110 phosphatase phosphatase NN 111 112 1 1 CD 113 116 and and CC 117 119 2A 2a NN 120 130 inhibitors inhibitor NNS 130 131 . . . 133 140 Protein protein NN 141 153 phosphatases phosphatas NNS 154 155 1 1 CD 156 159 and and CC 160 162 2A 2a NN 163 166 are be VBP 167 176 important important JJ 177 179 in in IN 180 190 regulating regulate VBG 191 199 cellular cellular JJ 200 209 functions function NNS 210 212 by by IN 213 224 controlling control VBG 225 228 the the DT 229 244 phosphorylation phosphorylation NN 245 250 state state NN 251 253 of of IN 254 259 their their PRP$ 260 270 substrates substrate NNS 270 271 . . . 272 274 In in IN 275 280 human human JJ 281 290 monocytes monocyte NNS 290 291 , , , 292 295 the the DT 296 306 inhibitors inhibitor NNS 307 309 of of IN 310 315 these these DT 316 328 phosphatases phosphatas NNS 328 329 , , , 330 337 okadaic okadaic JJ 338 342 acid acid NN 343 346 and and CC 347 356 calyculin calyculin NN 357 358 A a NN 358 359 , , , 360 364 were be VBD 365 370 found find VBN 371 373 to to TO 374 382 increase increase VB 383 386 the the DT 387 391 mRNA mrna NN 392 404 accumulation accumulation NN 405 408 and and CC 409 417 cytokine cytokine NN 418 428 production production NN 429 431 of of IN 432 445 interleukin-1 interleukin-1 NN 446 450 beta beta NN 451 454 and and CC 455 468 interleukin-1 interleukin-1 NN 469 474 alpha alpha NN 474 475 . . . 476 479 The the DT 480 489 increased increase VBN 490 494 mRNA mrna NN 495 507 accumulation accumulation NN 508 511 was be VBD 512 517 found find VBN 518 520 to to TO 521 523 be be VB 524 533 primarily primarily RB 534 541 because because IN 542 544 of of IN 545 548 the the DT 549 557 increase increase NN 558 560 in in IN 561 564 the the DT 565 578 transcription transcription NN 579 583 rate rate NN 584 586 of of IN 587 590 the the DT 591 604 interleukin-1 interleukin-1 NN 605 610 genes gene NNS 610 611 . . . 612 623 Stimulation stimulation NN 624 626 of of IN 627 640 interleukin-1 interleukin-1 NN 641 645 gene gene NN 646 659 transcription transcription NN 660 663 may may MD 664 666 be be VB 667 673 caused cause VBN 674 676 by by IN 677 680 the the DT 681 692 stimulation stimulation NN 693 695 of of IN 696 709 transcription transcription NN 710 716 factor factor NN 717 727 activities activity NNS 727 728 , , , 729 738 including include VBG 739 744 those those DT 745 747 of of IN 748 752 AP-1 ap-1 NN 752 753 , , , 754 756 by by IN 757 762 these these DT 763 770 protein protein NN 771 782 phosphatase phosphatase NN 783 793 inhibitors inhibitor NNS 793 794 . . . 795 802 Okadaic okadaic JJ 803 807 acid acid NN 808 817 increased increase VBD 818 821 the the DT 822 831 synthesis synthesis NN 832 834 of of IN 835 838 the the DT 839 852 interleukin-1 interleukin-1 NN 853 857 beta beta NN 858 867 precursor precursor NN 868 871 and and CC 872 878 mature mature JJ 879 884 forms form NNS 885 888 and and CC 889 894 their their PRP$ 895 904 secretion secretion NN 904 905 . . . 906 910 This this DT 911 920 increased increase VBN 921 931 processing processing NN 932 935 and and CC 936 945 secretion secretion NN 946 956 correlated correlate VBD 957 961 with with IN 962 965 the the DT 966 977 stimulation stimulation NN 978 980 of of IN 981 985 IL-1 il-1 NN 986 990 beta beta NN 991 1001 convertase convertase NN 1002 1006 mRNA mrna NN 1007 1019 accumulation accumulation NN 1019 1020 . . . 1021 1024 The the DT 1025 1036 stimulation stimulation NN 1037 1039 of of IN 1040 1053 interleukin-1 interleukin-1 NN 1054 1059 alpha alpha NN 1060 1070 production production NN 1071 1073 by by IN 1074 1081 okadaic okadaic JJ 1082 1086 acid acid NN 1087 1090 was be VBD 1091 1095 more more RBR 1096 1102 modest modest JJ 1103 1107 than than IN 1108 1112 that that DT 1113 1115 of of IN 1116 1129 interleukin-1 interleukin-1 NN 1130 1134 beta beta NN 1134 1135 . . . 1136 1143 However however RB 1143 1144 , , , 1145 1148 the the DT 1149 1164 phosphorylation phosphorylation NN 1165 1167 of of IN 1168 1171 the the DT 1172 1181 precursor precursor NN 1182 1195 interleukin-1 interleukin-1 NN 1196 1201 alpha alpha NN 1202 1210 cytokine cytokine NN 1211 1214 was be VBD 1215 1224 increased increase VBN 1224 1225 . . . 1226 1231 These these DT 1232 1239 results result NNS 1240 1244 show show VBP 1245 1249 that that IN 1250 1257 protein protein NN 1258 1269 phosphatase phosphatase NN 1270 1271 1 1 CD 1272 1275 and and CC 1276 1278 2A 2a NN 1279 1289 inhibitors inhibitor NNS 1290 1295 exert exert VBP 1296 1304 multiple multiple JJ 1305 1312 effects effect NNS 1313 1315 on on IN 1316 1324 cytokine cytokine NN 1325 1335 production production NN 1336 1338 in in IN 1339 1344 human human JJ 1345 1354 monocytes monocyte NNS 1355 1358 and and CC 1359 1366 suggest suggest VBP 1367 1371 that that IN 1372 1377 these these DT 1378 1381 two two CD 1382 1394 phosphatases phosphatas NNS 1395 1399 play play VBP 1400 1409 important important JJ 1410 1415 roles role NNS 1416 1418 in in IN 1419 1429 regulating regulate VBG 1430 1443 interleukin-1 interleukin-1 NN 1444 1454 production production NN 1454 1455 . . .