0 5 LMP-1 lmp-1 NN 6 15 activates activate VBZ 16 24 NF-kappa NF-kappa NNP 25 26 B B NNP 27 29 by by IN 30 39 targeting target VBG 40 43 the the DT 44 54 inhibitory inhibitory JJ 55 63 molecule molecule NN 64 65 I i NN 66 71 kappa kappa NN 72 73 B B NNP 74 79 alpha alpha NN 79 80 . . . 82 87 LMP-1 lmp-1 NN 87 88 , , , 89 91 an an DT 92 104 Epstein-Barr epstein-barr JJ 105 110 virus virus NN 111 119 membrane membrane NN 120 127 protein protein NN 128 137 expressed express VBN 138 144 during during IN 145 151 latent latent JJ 152 161 infection infection NN 161 162 , , , 163 166 has have VBZ 167 176 oncogenic oncogenic JJ 177 187 properties property NNS 187 188 , , , 189 191 as as IN 192 198 judged judge VBN 199 203 from from IN 204 207 its its PRP$ 208 215 ability ability NN 216 218 to to TO 219 228 transform transform VB 229 230 B B NNP 231 242 lymphocytes lymphocyte NNS 243 246 and and CC 247 253 rodent rodent JJ 254 265 fibroblasts fibroblast NNS 265 266 . . . 267 272 LMP-1 lmp-1 NN 273 280 induces induce VBZ 281 284 the the DT 285 295 expression expression NN 296 298 of of IN 299 303 bcl2 bcl2 NN 303 304 , , , 305 307 an an DT 308 316 oncogene oncogene NN 317 322 which which WDT 323 331 protects protect VBZ 332 337 cells cell NNS 338 342 from from IN 343 352 apoptosis apoptosis NN 352 353 , , , 354 356 as as RB 357 361 well well RB 362 364 as as IN 365 367 of of IN 368 373 genes gene NNS 374 382 encoding encode VBG 383 388 other other JJ 389 397 proteins protein NNS 398 406 involved involve VBN 407 409 in in IN 410 414 cell cell NN 415 425 regulation regulation NN 426 429 and and CC 430 436 growth growth NN 437 444 control control NN 444 445 . . . 446 449 The the DT 450 460 mechanisms mechanism NNS 461 463 by by IN 464 469 which which WDT 470 475 LMP-1 lmp-1 NN 476 487 upregulates upregulate VBZ 488 493 these these DT 494 502 proteins protein NNS 503 505 is be VBZ 506 513 unknown unknown JJ 513 514 , , , 515 518 but but CC 519 521 it it PRP 522 524 is be VBZ 525 534 plausible plausible JJ 535 539 that that IN 540 545 LMP-1 lmp-1 NN 546 554 modifies modify VBZ 555 561 signal signal NN 562 574 transduction transduction NN 575 583 pathways pathway NNS 584 588 that that WDT 589 595 result result VBP 596 598 in in IN 599 602 the the DT 603 613 activation activation NN 614 616 of of IN 617 620 one one CD 621 623 or or CC 624 628 more more JJR 629 642 transcription transcription NN 643 650 factors factor NNS 651 655 that that WDT 656 666 ultimately ultimately RB 667 675 regulate regulate VBP 676 689 transcription transcription NN 690 692 of of IN 693 702 oncogenic oncogenic JJ 703 708 genes gene NNS 708 709 . . . 710 718 NF-kappa NF-kappa NNP 719 720 B B NNP 720 721 , , , 722 723 a a DT 724 737 transcription transcription NN 738 744 factor factor NN 745 756 controlling control VBG 757 760 the the DT 761 771 expression expression NN 772 774 of of IN 775 780 genes gene NNS 781 789 involved involve VBN 790 792 in in IN 793 797 cell cell NN 798 808 activation activation NN 809 812 and and CC 813 819 growth growth NN 820 827 control control NN 827 828 , , , 829 832 has have VBZ 833 837 been be VBN 838 843 shown show VBN 844 846 to to TO 847 849 be be VB 850 859 activated activate VBN 860 862 by by IN 863 868 LMP-1 lmp-1 NN 868 869 . . . 870 873 The the DT 874 886 mechanism(s) mechanism(s) NN 887 897 regulating regulate VBG 898 902 this this DT 903 913 activation activation NN 914 921 remains remain VBZ 922 929 unknown unknown JJ 929 930 . . . 931 934 Our our PRP$ 935 939 data datum NNS 940 948 indicate indicate VBP 949 953 that that IN 954 963 increased increase VBN 964 972 NF-kappa NF-kappa NNP 973 974 B B NNP 975 978 DNA DNA NNP 979 986 binding binding NN 987 990 and and CC 991 1001 functional functional JJ 1002 1010 activity activity NN 1011 1014 are be VBP 1015 1022 present present JJ 1023 1025 in in IN 1026 1036 B-lymphoid b-lymphoid JJ 1037 1042 cells cell NNS 1043 1049 stably stably RB 1050 1052 or or CC 1053 1064 transiently transiently RB 1065 1075 expressing express VBG 1076 1082 LMP-1. lmp-1. JJ 1083 1084 I I NNP 1085 1090 kappa kappa NN 1091 1092 B B NNP 1093 1098 alpha alpha NN 1099 1101 is be VBZ 1102 1113 selectively selectively RB 1114 1122 modified modify VBN 1123 1125 in in IN 1126 1142 LMP-1-expressing lmp-1-expressing JJ 1143 1144 B B NNP 1145 1150 cells cell NNS 1150 1151 . . . 1152 1153 A a DT 1154 1168 phosphorylated phosphorylated JJ 1169 1173 form form NN 1174 1176 of of IN 1177 1178 I i NN 1179 1184 kappa kappa NN 1185 1186 B B NNP 1187 1192 alpha alpha NN 1193 1196 and and CC 1197 1206 increased increase VBN 1207 1214 protein protein NN 1215 1235 turnover-degradation turnover-degradation NN 1236 1245 correlate correlate VBP 1246 1250 with with IN 1251 1260 increased increase VBN 1261 1269 NF-kappa NF-kappa NNP 1270 1271 B B NNP 1272 1279 nuclear nuclear JJ 1280 1293 translocation translocation NN 1293 1294 . . . 1295 1299 This this DT 1300 1307 results result VBZ 1308 1310 in in IN 1311 1320 increased increase VBN 1321 1334 transcription transcription NN 1335 1337 of of IN 1338 1346 NF-kappa NF-kappa NNP 1347 1364 B-dependent-genes B-dependent-gene NNP 1364 1365 , , , 1366 1375 including include VBG 1376 1381 those those DT 1382 1390 encoding encode VBG 1391 1395 p105 p105 NN 1396 1399 and and CC 1400 1401 I i NN 1402 1407 kappa kappa NN 1408 1409 B B NNP 1410 1415 alpha alpha NN 1416 1417 ( ( ( 1417 1421 MAD3 MAD3 NNP 1421 1422 ) ) ) 1422 1423 . . . 1424 1429 These these DT 1430 1437 results result NNS 1438 1446 indicate indicate VBP 1447 1451 that that IN 1452 1457 LMP-1 lmp-1 NN 1458 1467 activates activate VBZ 1468 1476 NF-kappa NF-kappa NNP 1477 1478 B B NNP 1479 1481 in in IN 1482 1488 B-cell b-cell NN 1489 1494 lines line NNS 1495 1497 by by IN 1498 1507 targeting target VBG 1508 1509 I i NN 1510 1515 kappa kappa NN 1516 1517 B B NNP 1518 1523 alpha alpha NN 1523 1524 . . . 1525 1539 Identification identification NN 1540 1542 of of IN 1543 1546 the the DT 1547 1555 pathways pathway NNS 1556 1565 activated activate VBN 1566 1568 by by IN 1569 1574 LMP-1 lmp-1 NN 1575 1577 to to TO 1578 1584 result result VB 1585 1587 in in IN 1588 1605 posttranslational posttranslational JJ 1606 1619 modifications modification NNS 1620 1622 of of IN 1623 1624 I i NN 1625 1630 kappa kappa NN 1631 1632 B B NNP 1633 1638 alpha alpha NN 1639 1643 will will MD 1644 1647 aid aid VB 1648 1650 in in IN 1651 1662 determining determine VBG 1663 1666 the the DT 1667 1671 role role NN 1672 1674 of of IN 1675 1679 this this DT 1680 1690 virus-host virus-host JJ 1691 1695 cell cell NN 1696 1703 protein protein NN 1704 1715 interaction interaction NN 1716 1718 in in IN 1719 1731 Epstein-Barr epstein-barr JJ 1732 1746 virus-mediated virus-mediated JJ 1747 1758 oncogenesis oncogenesis NN 1758 1759 . . .