0 10 Expression expression NN 11 13 of of IN 14 16 Ah ah NN 17 25 receptor receptor NN 26 27 ( ( ( 27 31 TCDD TCDD NNP 32 40 receptor receptor NN 40 41 ) ) ) 42 48 during during IN 49 54 human human JJ 55 64 monocytic monocytic JJ 65 80 differentiation differentiation NN 80 81 . . . 83 85 We we PRP 86 90 have have VBP 91 101 previously previously RB 102 107 found find VBN 108 109 a a DT 110 114 high high JJ 115 125 expression expression NN 126 128 of of IN 129 134 human human JJ 135 137 Ah ah NN 138 146 receptor receptor NN 147 148 ( ( ( 148 152 TCDD TCDD NNP 153 161 receptor receptor NN 161 162 ) ) ) 163 167 mRNA mrna NN 168 170 in in IN 171 181 peripheral peripheral JJ 182 187 blood blood NN 188 193 cells cell NNS 194 196 of of IN 197 208 individuals individual NNS 208 209 . . . 210 212 In in IN 213 217 this this DT 218 223 paper paper NN 223 224 , , , 225 228 the the DT 229 239 expression expression NN 240 242 of of IN 243 247 this this DT 248 252 gene gene NN 253 255 in in IN 256 261 blood blood NN 262 267 cells cell NNS 268 271 was be VBD 272 277 first first RB 278 290 investigated investigate VBN 291 293 in in IN 294 303 fractions fraction NNS 304 306 of of IN 307 316 nucleated nucleated JJ 317 322 cells cell NNS 322 323 , , , 324 333 revealing reveal VBG 334 345 predominant predominant JJ 346 356 expression expression NN 357 359 of of IN 360 363 the the DT 364 366 Ah ah NN 367 375 receptor receptor NN 376 380 gene gene NN 381 383 in in IN 384 387 the the DT 388 396 monocyte monocyte NN 397 405 fraction fraction NN 405 406 . . . 407 411 Then then RB 412 415 the the DT 416 426 expression expression NN 427 433 levels level NNS 434 436 of of IN 437 440 AhR AhR NNP 441 445 mRNA mRNA NNP 446 448 in in IN 449 456 various various JJ 457 470 hematopoietic hematopoietic JJ 471 475 cell cell NN 476 481 lines line NNS 482 486 were be VBD 487 495 examined examine VBN 496 504 together together RB 505 509 with with IN 510 515 those those DT 516 518 of of IN 519 523 Arnt Arnt NNP 524 527 and and CC 528 535 P450IA1 P450IA1 NNP 535 536 . . . 537 540 AhR AhR NNP 541 544 was be VBD 545 554 expressed express VBN 555 557 at at IN 558 562 high high JJ 563 569 levels level NNS 570 572 in in IN 573 583 monocytoid monocytoid JJ 584 588 U937 u937 NN 588 589 , , , 590 594 THP1 THP1 NNP 594 595 , , , 596 599 and and CC 600 605 HEL/S HEL/S NNP 606 611 cells cell NNS 611 612 , , , 613 616 and and CC 617 619 at at IN 620 628 moderate moderate JJ 629 635 levels level NNS 636 638 in in IN 639 652 promyelocytic promyelocytic JJ 653 657 HL60 hl60 NN 658 663 cells cell NNS 664 667 and and CC 668 682 erythroblastic erythroblastic JJ 683 686 HEL hel NN 687 692 cells cell NNS 692 693 . . . 694 701 However however RB 701 702 , , , 703 705 it it PRP 706 709 was be VBD 710 713 not not RB 714 722 detected detect VBN 723 725 in in IN 726 734 lymphoid lymphoid JJ 735 740 cells cell NNS 741 746 MOLT4 molt4 NN 747 748 ( ( ( 748 749 T t NN 750 754 cell cell NN 754 755 ) ) ) 756 759 and and CC 760 765 BALL1 BALL1 NNP 766 767 ( ( ( 767 768 B B NNP 769 773 cell cell NN 773 774 ) ) ) 774 775 , , , 776 779 nor nor CC 780 782 in in IN 783 787 K562 k562 NN 788 801 erythroblasts erythroblast NNS 801 802 . . . 803 814 Furthermore furthermore RB 814 815 , , , 816 817 a a DT 818 826 specific specific JJ 827 836 induction induction NN 837 839 of of IN 840 843 AhR ahr NN 844 850 during during IN 851 860 monocytic monocytic JJ 861 876 differentiation differentiation NN 877 880 was be VBD 881 893 investigated investigate VBN 894 896 in in IN 897 901 HL60 HL60 NNP 902 905 and and CC 906 909 HEL HEL NNP 910 915 cells cell NNS 915 916 . . . 917 921 HL60 HL60 NNP 922 927 cells cell NNS 928 932 were be VBD 933 940 induced induce VBN 941 943 to to TO 944 957 differentiate differentiate VB 958 964 toward toward IN 965 986 monocytes-macrophages monocytes-macrophage NNS 987 989 by by IN 990 1000 incubation incubation NN 1001 1005 with with IN 1006 1013 phorbol phorbol NN 1014 1019 ester ester NN 1019 1020 , , , 1021 1028 showing show VBG 1029 1030 a a DT 1031 1033 5- 5- CD 1034 1036 to to TO 1037 1043 2-fold 2-fold JJ 1044 1052 increase increase NN 1053 1055 of of IN 1056 1059 AhR AhR NNP 1060 1064 mRNA mRNA NNP 1064 1065 . . . 1066 1069 The the DT 1070 1080 incubation incubation NN 1081 1085 with with IN 1086 1098 transforming transform VBG 1099 1105 growth growth NN 1106 1112 factor factor NN 1113 1117 beta beta NN 1118 1119 1 1 CD 1120 1123 and and CC 1124 1125 1 1 CD 1126 1151 alpha,25-dihydroxyvitamin alpha,25-dihydroxyvitamin NN 1152 1154 D3 d3 NN 1155 1163 resulted result VBD 1164 1166 in in IN 1167 1168 a a DT 1169 1171 5- 5- CD 1172 1174 to to TO 1175 1181 7-fold 7-fold JJ 1182 1190 increase increase NN 1191 1193 of of IN 1194 1197 AhR AhR NNP 1198 1202 mRNA mRNA NNP 1202 1203 . . . 1204 1207 The the DT 1208 1211 HEL HEL NNP 1212 1217 cells cell NNS 1218 1222 also also RB 1223 1232 exhibited exhibit VBD 1233 1234 a a DT 1235 1242 similar similar JJ 1243 1252 elevation elevation NN 1253 1255 of of IN 1256 1259 AhR AhR NNP 1260 1264 mRNA mRNA NNP 1265 1270 level level NN 1270 1271 , , , 1272 1276 when when WRB 1277 1281 they they PRP 1282 1285 had have VBD 1286 1300 differentiated differentiate VBN 1301 1307 toward toward IN 1308 1327 monocyte-macrophage monocyte-macrophage JJ 1328 1333 cells cell NNS 1334 1336 by by IN 1337 1342 these these DT 1343 1351 combined combine VBN 1352 1360 inducers inducer NNS 1360 1361 , , , 1362 1365 but but CC 1366 1372 little little JJ 1373 1379 change change NN 1380 1382 in in IN 1383 1386 the the DT 1387 1391 mRNA mrna NN 1392 1397 level level NN 1398 1401 was be VBD 1402 1410 observed observe VBN 1411 1415 when when WRB 1416 1419 the the DT 1420 1425 cells cell NNS 1426 1430 were be VBD 1431 1438 induced induce VBN 1439 1441 to to TO 1442 1455 differentiate differentiate VB 1456 1460 into into IN 1461 1466 other other JJ 1467 1471 cell cell NN 1472 1477 types type NNS 1477 1478 . . . 1479 1488 Treatment Treatment NNP 1489 1491 of of IN 1492 1495 the the DT 1496 1510 differentiated differentiate VBN 1511 1515 HL60 hl60 NN 1516 1521 cells cell NNS 1522 1526 with with IN 1527 1547 3-methylcholanthrene 3-methylcholanthrene NN 1547 1548 , , , 1549 1550 a a DT 1551 1557 ligand ligand NN 1558 1560 of of IN 1561 1564 AhR AhR NNP 1564 1565 , , , 1566 1573 induced induce VBD 1574 1577 the the DT 1578 1588 expression expression NN 1589 1591 of of IN 1592 1595 the the DT 1596 1603 P450IA1 p450ia1 NN 1604 1608 gene gene NN 1608 1609 . . . 1610 1615 These these DT 1616 1623 results result NNS 1624 1633 indicated indicate VBD 1634 1638 that that IN 1639 1649 expression expression NN 1650 1652 of of IN 1653 1656 AhR AhR NNP 1657 1661 mRNA mRNA NNP 1662 1665 was be VBD 1666 1679 significantly significantly RB 1680 1687 induced induce VBN 1688 1694 during during IN 1695 1704 monocytic monocytic JJ 1705 1720 differentiation differentiation NN 1721 1724 and and CC 1725 1729 that that IN 1730 1733 the the DT 1734 1748 differentiated differentiate VBN 1749 1754 cells cell NNS 1755 1759 were be VBD 1760 1770 responsive responsive JJ 1771 1773 to to TO 1774 1785 xenobiotics xenobiotic NNS 1785 1786 . . . 1787 1790 Our our PRP$ 1791 1798 results result NNS 1799 1806 suggest suggest VBP 1807 1811 that that IN 1812 1815 AhR AhR NNP 1816 1819 may may MD 1820 1824 play play VB 1825 1827 an an DT 1828 1837 important important JJ 1838 1842 role role NN 1843 1845 in in IN 1846 1849 the the DT 1850 1858 function function NN 1859 1861 of of IN 1862 1871 monocytes monocyte NNS 1872 1875 and and CC 1876 1880 also also RB 1881 1883 in in IN 1884 1887 the the DT 1888 1896 eventual eventual JJ 1897 1907 activation activation NN 1908 1910 of of IN 1911 1924 environmental environmental JJ 1925 1936 carcinogens carcinogen NNS 1936 1937 . . .