0	19	Adherence-dependent	adherence-dependent	JJ
20	28	increase	increase	NN
29	31	in	in	IN
32	37	human	human	JJ
38	46	monocyte	monocyte	NN
47	54	PDGF(B)	PDGF(B)	NNP
55	59	mRNA	mRNA	NNP
60	62	is	be	VBZ
63	73	associated	associate	VBN
74	78	with	with	IN
79	88	increases	increase	NNS
89	91	in	in	IN
92	97	c-fos	c-fos	NN
97	98	,	,	,
99	104	c-jun	c-jun	NN
104	105	,	,	,
106	109	and	and	CC
110	114	EGR2	EGR2	NNP
115	119	mRNA	mRNA	NNP
119	120	.	.	.

122	131	Adherence	Adherence	NNP
132	134	is	be	VBZ
135	137	an	an	DT
138	147	important	important	JJ
148	155	initial	initial	JJ
156	160	step	step	NN
161	163	in	in	IN
164	167	the	the	DT
168	178	transition	transition	NN
179	181	of	of	IN
182	183	a	a	DT
184	195	circulating	circulate	VBG
196	204	monocyte	monocyte	NN
205	207	to	to	TO
208	209	a	a	DT
210	216	tissue	tissue	NN
217	227	macrophage	macrophage	NN
227	228	.	.	.

229	233	This	this	DT
234	249	differentiation	differentiation	NN
250	252	is	be	VBZ
253	264	accompanied	accompany	VBN
265	267	by	by	IN
268	270	an	an	DT
271	280	augmented	augmented	JJ
281	289	capacity	capacity	NN
290	292	to	to	TO
293	301	generate	generate	VB
302	308	growth	growth	NN
309	316	factors	factor	NNS
316	317	.	.	.

318	320	We	we	PRP
321	333	hypothesized	hypothesize	VBD
334	338	that	that	IN
339	348	adherence	adherence	NN
349	355	itself	itself	PRP
356	361	might	might	MD
362	364	be	be	VB
365	367	an	an	DT
368	377	important	important	JJ
378	385	trigger	trigger	NN
386	389	for	for	IN
390	391	a	a	DT
392	400	sequence	sequence	NN
401	403	of	of	IN
404	408	gene	gene	NN
409	419	activation	activation	NN
420	431	culminating	culminate	VBG
432	434	in	in	IN
435	440	cells	cell	NNS
441	445	with	with	IN
446	455	increased	increase	VBN
456	460	mRNA	mrna	NN
461	469	encoding	encode	VBG
470	481	profibrotic	profibrotic	JJ
482	488	growth	growth	NN
489	496	factors	factor	NNS
497	501	such	such	JJ
502	504	as	as	IN
505	521	platelet-derived	platelet-derived	JJ
522	528	growth	growth	NN
529	535	factor	factor	NN
536	537	B	B	NNP
538	545	subunit	subunit	NN
546	547	(	(	(
547	553	PDGF[B	PDGF[B	NNP
553	554	]	]	)
554	555	)	)	)
556	559	and	and	CC
560	572	transforming	transform	VBG
573	579	growth	growth	NN
580	591	factor-beta	factor-beta	NN
592	593	(	(	(
593	601	TGF-beta	TGF-beta	NNP
601	602	)	)	)
602	603	.	.	.

604	609	After	after	IN
610	612	in	in	FW
613	618	vitro	vitro	FW
619	628	adherence	adherence	NN
628	629	,	,	,
630	635	human	human	JJ
636	645	monocytes	monocyte	NNS
646	649	had	have	VBD
650	651	a	a	DT
652	660	biphasic	biphasic	JJ
661	669	increase	increase	NN
670	672	in	in	IN
673	680	PDGF(B)	PDGF(B)	NNP
681	685	mRNA	mRNA	NNP
686	690	with	with	IN
691	696	peaks	peak	NNS
697	699	at	at	IN
700	701	6	6	CD
702	703	h	h	NN
704	707	and	and	CC
708	710	13	13	CD
711	712	d	d	NN
712	713	.	.	.

714	716	No	no	DT
717	725	increase	increase	NN
726	728	in	in	IN
729	737	TGF-beta	TGF-beta	NNP
738	742	mRNA	mRNA	NNP
743	746	was	be	VBD
747	755	observed	observe	VBN
755	756	.	.	.

757	760	The	the	DT
761	764	6-h	6-h	JJ
765	773	increase	increase	NN
774	776	in	in	IN
777	784	PDGF(B)	PDGF(B)	NNP
785	789	mRNA	mRNA	NNP
790	793	was	be	VBD
794	803	adherence	adherence	NN
804	813	dependent	dependent	JJ
813	814	,	,	,
815	818	and	and	CC
819	821	in	in	IN
822	830	addition	addition	NN
830	831	,	,	,
832	835	was	be	VBD
836	845	abrogated	abrogate	VBN
846	850	when	when	WRB
851	854	the	the	DT
855	867	cytoskeletal	cytoskeletal	JJ
868	877	integrity	integrity	NN
878	881	was	be	VBD
882	893	compromised	compromise	VBN
894	896	by	by	IN
897	909	cytochalasin	cytochalasin	NN
910	912	D.	D.	NNP
913	916	The	the	DT
917	920	6-h	6-h	JJ
921	929	increase	increase	NN
930	932	in	in	IN
933	940	PDGF(B)	PDGF(B)	NNP
941	945	mRNA	mRNA	NNP
946	949	was	be	VBD
950	959	unaltered	unaltered	JJ
960	962	by	by	IN
963	972	adherence	adherence	NN
973	975	in	in	IN
976	979	the	the	DT
980	988	presence	presence	NN
989	991	of	of	IN
992	995	the	the	DT
996	1004	monocyte	monocyte	NN
1005	1013	stimulus	stimulus	NN
1014	1032	lipopolysaccharide	lipopolysaccharide	NN
1032	1033	.	.	.

1034	1043	Adherence	Adherence	NNP
1044	1046	to	to	TO
1047	1053	either	either	CC
1054	1065	fibronectin	fibronectin	NN
1066	1068	or	or	CC
1069	1084	collagen-coated	collagen-coated	JJ
1085	1092	plastic	plastic	NN
1093	1096	had	have	VBD
1097	1103	little	little	JJ
1104	1114	consistent	consistent	JJ
1115	1121	effect	effect	NN
1122	1124	on	on	IN
1125	1132	PDGF(B)	pdgf(b)	NN
1133	1137	mRNA	mrna	NN
1138	1150	accumulation	accumulation	NN
1150	1151	.	.	.

1152	1155	The	the	DT
1156	1165	increased	increase	VBN
1166	1173	PDGF(B)	PDGF(B)	NNP
1174	1178	mRNA	mRNA	NNP
1179	1187	observed	observe	VBN
1188	1190	in	in	IN
1191	1199	adherent	adherent	JJ
1200	1209	monocytes	monocyte	NNS
1210	1213	was	be	VBD
1214	1225	accompanied	accompany	VBN
1226	1228	by	by	IN
1229	1238	increases	increase	NNS
1239	1241	in	in	IN
1242	1247	mRNAs	mrna	NNS
1248	1250	of	of	IN
1251	1254	the	the	DT
1255	1260	early	early	JJ
1261	1267	growth	growth	NN
1268	1276	response	response	NN
1277	1282	genes	gene	NNS
1283	1288	c-fos	c-fos	NN
1289	1290	(	(	(
1290	1297	maximal	maximal	JJ
1298	1300	at	at	IN
1301	1303	20	20	CD
1304	1307	min	min	NN
1307	1308	)	)	)
1308	1309	,	,	,
1310	1315	c-jun	c-jun	NN
1315	1316	,	,	,
1317	1320	and	and	CC
1321	1325	EGR2	egr2	NN
1326	1327	(	(	(
1327	1334	maximal	maximal	JJ
1335	1337	at	at	IN
1338	1342	6-24	6-24	CD
1343	1344	h	h	NN
1344	1345	)	)	)
1345	1346	.	.	.

1347	1350	The	the	DT
1351	1359	increase	increase	NN
1360	1362	in	in	IN
1363	1368	c-jun	c-jun	NN
1369	1372	and	and	CC
1373	1377	EGR2	egr2	NN
1377	1378	,	,	,
1379	1382	but	but	CC
1383	1386	not	not	RB
1387	1392	c-fos	c-fos	NN
1392	1393	,	,	,
1394	1398	mRNA	mRNA	NNP
1399	1402	was	be	VBD
1403	1407	also	also	RB
1408	1417	abrogated	abrogate	VBN
1418	1420	by	by	IN
1421	1433	cytochalasin	cytochalasin	NN
1434	1435	D	D	NNP
1435	1436	.	.	.

1437	1442	These	these	DT
1443	1455	observations	observation	NNS
1456	1463	suggest	suggest	VBP
1464	1468	that	that	IN
1469	1478	adherence	adherence	NN
1479	1486	results	result	VBZ
1487	1489	in	in	IN
1490	1499	increases	increase	NNS
1500	1502	of	of	IN
1503	1508	c-fos	c-fos	NN
1508	1509	,	,	,
1510	1515	c-jun	c-jun	NN
1515	1516	,	,	,
1517	1521	EGR2	EGR2	NNP
1521	1522	,	,	,
1523	1526	and	and	CC
1527	1534	PDGF(B)	PDGF(B)	NNP
1535	1539	mRNA	mRNA	NNP
1539	1540	.	.	.

1541	1543	In	in	IN
1544	1552	addition	addition	NN
1552	1553	,	,	,
1554	1557	the	the	DT
1558	1567	increases	increase	NNS
1568	1570	in	in	IN
1571	1576	c-jun	c-jun	NN
1576	1577	,	,	,
1578	1582	EGR2	EGR2	NNP
1582	1583	,	,	,
1584	1587	and	and	CC
1588	1595	PDGF(B)	PDGF(B)	NNP
1596	1599	may	may	MD
1600	1606	depend	depend	VB
1607	1609	on	on	IN
1610	1622	cytoskeletal	cytoskeletal	JJ
1623	1636	rearrangement	rearrangement	NN
1636	1637	.	.	.

1638	1648	Modulation	modulation	NN
1649	1651	of	of	IN
1652	1657	these	these	DT
1658	1664	events	event	NNS
1665	1667	at	at	IN
1668	1671	the	the	DT
1672	1676	time	time	NN
1677	1679	of	of	IN
1680	1689	adherence	adherence	NN
1690	1696	offers	offer	VBZ
1697	1698	a	a	DT
1699	1708	mechanism	mechanism	NN
1709	1711	by	by	IN
1712	1717	which	which	WDT
1718	1730	differential	differential	JJ
1731	1738	priming	priming	NN
1739	1741	of	of	IN
1742	1745	the	the	DT
1746	1751	cells	cell	NNS
1752	1755	may	may	MD
1756	1758	be	be	VB
1759	1771	accomplished	accomplish	VBN
1771	1772	.	.	.