0	14	Retinoblastoma	retinoblastoma	NN
15	22	protein	protein	NN
23	33	expression	expression	NN
34	39	leads	lead	VBZ
40	42	to	to	TO
43	50	reduced	reduce	VBN
51	56	Oct-1	oct-1	NN
57	60	DNA	dna	NN
61	68	binding	binding	NN
69	77	activity	activity	NN
78	81	and	and	CC
82	90	enhances	enhance	VBZ
91	104	interleukin-8	interleukin-8	NN
105	115	expression	expression	NN
115	116	.	.	.

118	123	Tumor	tumor	NN
124	128	cell	cell	NN
129	134	lines	line	NNS
135	139	with	with	IN
140	141	a	a	DT
142	151	defective	defective	JJ
152	166	retinoblastoma	retinoblastoma	NN
167	171	gene	gene	NN
172	175	are	be	VBP
176	182	unable	unable	JJ
183	185	to	to	TO
186	196	transcribe	transcribe	VB
197	200	the	the	DT
201	204	HLA	HLA	NNP
205	210	class	class	NN
211	213	II	ii	CD
214	219	genes	gene	NNS
220	222	in	in	IN
223	231	response	response	NN
232	234	to	to	TO
235	244	IFN-gamma	IFN-gamma	NNP
245	254	treatment	treatment	NN
254	255	,	,	,
256	259	and	and	CC
260	274	reconstitution	reconstitution	NN
275	277	of	of	IN
278	288	functional	functional	JJ
289	291	Rb	Rb	NNP
292	299	rescues	rescue	VBZ
300	317	IFN-gamma-induced	ifn-gamma-induced	JJ
318	323	class	class	NN
324	326	II	ii	CD
327	331	gene	gene	NN
332	342	expression	expression	NN
342	343	.	.	.

344	351	However	however	RB
351	352	,	,	,
353	356	the	the	DT
357	366	molecular	molecular	JJ
367	376	mechanism	mechanism	NN
377	379	of	of	IN
380	382	Rb	Rb	NNP
383	389	rescue	rescue	NN
390	392	of	of	IN
393	396	the	the	DT
397	402	class	class	NN
403	405	II	ii	CD
406	411	genes	gene	NNS
412	414	is	be	VBZ
415	422	unknown	unknown	JJ
422	423	.	.	.

424	426	We	we	PRP
427	431	have	have	VBP
432	440	examined	examine	VBN
441	444	the	the	DT
445	451	effect	effect	NN
452	454	of	of	IN
455	457	Rb	Rb	NNP
458	468	expression	expression	NN
469	471	on	on	IN
472	475	the	the	DT
476	486	activation	activation	NN
487	489	of	of	IN
490	493	the	the	DT
494	502	promoter	promoter	NN
503	506	for	for	IN
507	514	HLA-DRA	HLA-DRA	NNP
514	515	,	,	,
516	519	the	the	DT
520	529	prototype	prototype	NN
530	535	class	class	NN
536	538	II	ii	CD
539	543	gene	gene	NN
543	544	.	.	.

545	550	Oct-1	Oct-1	NNP
550	551	,	,	,
552	553	a	a	DT
554	557	POU	POU	NNP
558	564	domain	domain	NN
565	578	transcription	transcription	NN
579	585	factor	factor	NN
585	586	,	,	,
587	590	was	be	VBD
591	601	identified	identify	VBN
602	604	as	as	IN
605	606	a	a	DT
607	616	repressor	repressor	NN
617	619	of	of	IN
620	627	HLA-DRA	HLA-DRA	NNP
628	636	promoter	promoter	NN
637	645	activity	activity	NN
646	648	in	in	IN
649	652	the	the	DT
653	665	Rb-defective	rb-defective	JJ
666	671	cells	cell	NNS
671	672	.	.	.

673	675	Rb	Rb	NNP
676	686	expression	expression	NN
687	690	led	lead	VBD
691	693	to	to	TO
694	709	phosphorylation	phosphorylation	NN
710	712	of	of	IN
713	718	Oct-1	oct-1	NN
718	719	,	,	,
720	724	thus	thus	RB
725	734	relieving	relieve	VBG
735	738	its	its	PRP$
739	749	repressive	repressive	JJ
750	756	effect	effect	NN
756	757	.	.	.

758	763	Oct-1	Oct-1	NNP
764	767	has	have	VBZ
768	772	also	also	RB
773	777	been	be	VBN
778	783	shown	show	VBN
784	786	to	to	TO
787	794	repress	repress	VB
795	806	interleukin	interleukin	NN
807	808	8	8	CD
809	817	promoter	promoter	NN
818	826	activity	activity	NN
826	827	.	.	.

828	838	Consistent	consistent	JJ
839	843	with	with	IN
844	851	reduced	reduce	VBN
852	858	levels	level	NNS
859	861	of	of	IN
862	867	Oct-1	oct-1	NN
868	871	DNA	DNA	NNP
872	879	binding	binding	NN
880	888	activity	activity	NN
889	891	in	in	IN
892	895	the	the	DT
896	910	Rb-transformed	rb-transformed	JJ
911	915	cell	cell	NN
916	921	lines	line	NNS
921	922	,	,	,
923	934	interleukin	interleukin	NN
935	936	8	8	CD
937	947	expression	expression	NN
948	950	is	be	VBZ
951	957	higher	high	JJR
958	960	in	in	IN
961	966	these	these	DT
967	971	cell	cell	NN
972	977	lines	line	NNS
977	978	.	.	.