0 13 Rel/NF-kappaB Rel/NF-kappaB NNP 14 17 can can MD 18 25 trigger trigger VB 26 29 the the DT 30 35 Notch Notch NNP 36 45 signaling signaling NN 46 53 pathway pathway NN 54 56 by by IN 57 65 inducing induce VBG 66 69 the the DT 70 80 expression expression NN 81 83 of of IN 84 91 Jagged1 Jagged1 NNP 91 92 , , , 93 94 a a DT 95 101 ligand ligand NN 102 105 for for IN 106 111 Notch Notch NNP 112 121 receptors receptor NNS 121 122 . . . 124 131 Jagged1 Jagged1 NNP 132 139 belongs belong VBZ 140 142 to to TO 143 146 the the DT 147 150 DSL DSL NNP 151 157 family family NN 158 160 of of IN 161 168 ligands ligand NNS 169 172 for for IN 173 178 Notch Notch NNP 179 188 receptors receptor NNS 189 193 that that WDT 194 201 control control VBP 202 205 the the DT 206 219 proliferation proliferation NN 220 223 and and CC 224 239 differentiation differentiation NN 240 242 of of IN 243 250 various various JJ 251 255 cell cell NN 256 264 lineages lineage NNS 264 265 . . . 266 273 However however RB 273 274 , , , 275 281 little little JJ 282 284 is be VBZ 285 290 known know VBN 291 296 about about IN 297 300 the the DT 301 314 transcription transcription NN 315 322 factors factor NNS 323 327 that that WDT 328 336 regulate regulate VBP 337 340 its its PRP$ 341 351 expression expression NN 351 352 . . . 353 357 Here here RB 357 358 , , , 359 361 we we PRP 362 366 show show VBP 367 371 that that IN 372 379 Jagged1 jagged1 NN 380 382 is be VBZ 383 384 a a DT 385 409 Rel/NF-kappaB-responsive rel/nf-kappab-responsive JJ 410 414 gene gene NN 414 415 . . . 416 420 Both both CC 421 426 c-Rel c-rel NN 427 430 and and CC 431 435 RelA RelA NNP 436 443 induced induce VBD 444 451 jagged1 jagged1 NN 452 456 gene gene NN 457 467 expression expression NN 467 468 , , , 469 476 whereas whereas IN 477 478 a a DT 479 485 mutant mutant NN 486 495 defective defective JJ 496 499 for for IN 500 515 transactivation transactivation NN 516 519 did do VBD 520 523 not not RB 523 524 . . . 525 536 Importantly importantly RB 536 537 , , , 538 545 jagged1 jagged1 NN 546 557 transcripts transcript NNS 558 562 were be VBD 563 567 also also RB 568 579 upregulated upregulate VBN 580 582 by by IN 583 593 endogenous endogenous JJ 594 603 NF-kappaB NF-kappaB NNP 604 614 activation activation NN 615 618 and and CC 619 623 this this DT 624 630 effect effect NN 631 634 was be VBD 635 644 inhibited inhibit VBN 645 647 by by IN 648 649 a a DT 650 658 dominant dominant JJ 659 665 mutant mutant NN 666 668 of of IN 669 681 IkappaBalpha IkappaBalpha NNP 681 682 , , , 683 684 a a DT 685 698 physiological physiological JJ 699 708 inhibitor inhibitor NN 709 711 of of IN 712 721 NF-kappaB NF-kappaB NNP 721 722 . . . 723 727 Cell cell NN 728 735 surface surface NN 736 746 expression expression NN 747 749 of of IN 750 757 Jagged1 jagged1 NN 758 760 in in IN 761 777 c-Rel-expressing c-rel-expressing NN 778 782 cell cell NN 783 793 monolayers monolayer NNS 794 797 led lead VBD 798 800 to to TO 801 802 a a DT 803 813 functional functional JJ 814 825 interaction interaction NN 826 830 with with IN 831 842 lymphocytes lymphocyte NNS 843 853 expressing express VBG 854 857 the the DT 858 870 Notch1/TAN-1 notch1/tan-1 NN 871 879 receptor receptor NN 879 880 . . . 881 885 This this DT 886 896 correlated correlate VBD 897 901 with with IN 902 905 the the DT 906 916 initiation initiation NN 917 919 of of IN 920 929 signaling signaling NN 930 940 downstream downstream RB 941 943 of of IN 944 949 Notch Notch NNP 949 950 , , , 951 953 as as IN 954 963 evidenced evidence VBN 964 966 by by IN 967 976 increased increase VBN 977 983 levels level NNS 984 986 of of IN 987 992 HES-1 hes-1 NN 993 1004 transcripts transcript NNS 1005 1007 in in IN 1008 1021 co-cultivated co-cultivated JJ 1022 1023 T t NN 1024 1029 cells cell NNS 1030 1033 and and CC 1034 1036 of of IN 1037 1041 CD23 cd23 NN 1042 1053 transcripts transcript NNS 1054 1056 in in IN 1057 1070 co-cultivated co-cultivated JJ 1071 1072 B b NN 1073 1078 cells cell NNS 1078 1079 . . . 1080 1090 Consistent consistent JJ 1091 1095 with with IN 1096 1099 its its PRP$ 1100 1123 Rel/NF-kappaB-dependent rel/nf-kappab-dependent JJ 1124 1133 induction induction NN 1133 1134 , , , 1135 1142 Jagged1 Jagged1 NNP 1143 1146 was be VBD 1147 1152 found find VBN 1153 1155 to to TO 1156 1158 be be VB 1159 1165 highly highly RB 1166 1175 expressed express VBN 1176 1178 in in IN 1179 1186 splenic splenic JJ 1187 1188 B B NNP 1189 1194 cells cell NNS 1195 1200 where where WRB 1201 1206 c-Rel c-rel NN 1207 1209 is be VBZ 1210 1219 expressed express VBN 1220 1234 constitutively constitutively RB 1234 1235 . . . 1236 1241 These these DT 1242 1249 results result NNS 1250 1261 demonstrate demonstrate VBP 1262 1266 that that IN 1267 1272 c-Rel c-rel NN 1273 1276 can can MD 1277 1284 trigger trigger VB 1285 1288 the the DT 1289 1294 Notch Notch NNP 1295 1304 signaling signaling NN 1305 1312 pathway pathway NN 1313 1315 in in IN 1316 1327 neighboring neighbor VBG 1328 1333 cells cell NNS 1334 1336 by by IN 1337 1345 inducing induce VBG 1346 1353 jagged1 jagged1 NN 1354 1358 gene gene NN 1359 1369 expression expression NN 1369 1370 , , , 1371 1374 and and CC 1375 1382 suggest suggest VBP 1383 1384 a a DT 1385 1389 role role NN 1390 1393 for for IN 1394 1401 Jagged1 jagged1 NN 1402 1404 in in IN 1405 1411 B-cell b-cell NN 1412 1422 activation activation NN 1422 1423 , , , 1424 1439 differentiation differentiation NN 1440 1442 or or CC 1443 1451 function function NN 1451 1452 . . . 1453 1458 These these DT 1459 1467 findings finding NNS 1468 1472 also also RB 1473 1482 highlight highlight VBP 1483 1486 the the DT 1487 1496 potential potential NN 1497 1500 for for IN 1501 1503 an an DT 1504 1513 interplay interplay NN 1514 1521 between between IN 1522 1525 the the DT 1526 1531 Notch Notch NNP 1532 1535 and and CC 1536 1545 NF-kappaB NF-kappaB NNP 1546 1555 signaling signaling NN 1556 1564 pathways pathway NNS 1565 1567 in in IN 1568 1571 the the DT 1572 1578 immune immune JJ 1579 1585 system system NN 1585 1586 . . .