0	4	CD40	CD40	NNP
4	5	,	,	,
6	9	but	but	CC
10	13	not	not	RB
14	32	lipopolysaccharide	lipopolysaccharide	NN
33	36	and	and	CC
37	45	anti-IgM	anti-igm	JJ
46	57	stimulation	stimulation	NN
58	60	of	of	IN
61	68	primary	primary	JJ
69	70	B	B	NNP
71	82	lymphocytes	lymphocyte	NNS
82	83	,	,	,
84	89	leads	lead	VBZ
90	92	to	to	TO
93	94	a	a	DT
95	105	persistent	persistent	JJ
106	113	nuclear	nuclear	JJ
114	126	accumulation	accumulation	NN
127	129	of	of	IN
130	134	RelB	RelB	NNP
134	135	.	.	.

137	139	In	in	IN
140	144	this	this	DT
145	150	study	study	NN
151	153	we	we	PRP
154	162	analyzed	analyze	VBD
163	166	the	the	DT
167	173	effect	effect	NN
174	176	of	of	IN
177	181	CD40	cd40	NN
182	193	stimulation	stimulation	NN
194	196	on	on	IN
197	200	the	the	DT
201	209	activity	activity	NN
210	213	and	and	CC
214	221	nuclear	nuclear	JJ
222	232	appearance	appearance	NN
233	235	of	of	IN
236	247	Rel/nuclear	rel/nuclear	JJ
248	254	factor	factor	NN
255	261	kappaB	kappaB	NNP
262	263	(	(	(
263	272	NF-kappaB	NF-kappaB	NNP
272	273	)	)	)
274	281	factors	factor	NNS
282	284	in	in	IN
285	292	primary	primary	JJ
293	299	murine	murine	JJ
300	301	B	B	NNP
302	313	lymphocytes	lymphocyte	NNS
313	314	.	.	.

315	317	We	we	PRP
318	322	show	show	VBP
323	327	that	that	IN
328	338	triggering	triggering	NN
339	341	of	of	IN
342	346	CD40	cd40	NN
347	356	signaling	signaling	NN
357	367	pathway(s)	pathway(s)	NN
368	370	by	by	IN
371	375	CD40	CD40	NNP
376	383	ligands	ligand	NNS
384	393	expressed	express	VBN
394	396	on	on	IN
397	398	L	L	NNP
399	404	cells	cell	NNS
405	408	led	lead	VBD
409	411	to	to	TO
412	418	strong	strong	JJ
419	429	activation	activation	NN
430	432	of	of	IN
433	435	an	an	DT
436	456	NF-kappaB-controlled	nf-kappab-controlled	JJ
457	468	beta-globin	beta-globin	NN
469	477	reporter	reporter	NN
478	482	gene	gene	NN
483	485	in	in	IN
486	493	primary	primary	JJ
494	495	B	B	NNP
496	507	lymphocytes	lymphocyte	NNS
508	512	from	from	IN
513	523	transgenic	transgenic	JJ
524	528	mice	mouse	NNS
528	529	.	.	.

530	538	Analyses	analysis	NNS
539	541	of	of	IN
542	549	nuclear	nuclear	JJ
550	563	translocation	translocation	NN
564	566	of	of	IN
567	577	individual	individual	JJ
578	585	members	member	NNS
586	588	of	of	IN
589	592	Rel	Rel	NNP
593	601	proteins	protein	NNS
602	607	after	after	IN
608	612	CD40	cd40	NN
613	622	induction	induction	NN
623	625	of	of	IN
626	633	primary	primary	JJ
634	635	B	B	NNP
636	641	cells	cell	NNS
642	648	showed	show	VBD
649	650	a	a	DT
651	657	strong	strong	JJ
658	661	and	and	CC
662	674	long-lasting	long-lasting	JJ
675	687	accumulation	accumulation	NN
688	690	of	of	IN
691	695	RelB	RelB	NNP
696	699	and	and	CC
699	700	,	,	,
701	705	less	less	RBR
706	716	pronounced	pronounced	JJ
716	717	,	,	,
718	720	of	of	IN
721	726	c-Rel	c-rel	NN
726	727	.	.	.

728	731	LPS	LPS	NNP
732	743	stimulation	stimulation	NN
744	747	did	do	VBD
748	751	not	not	RB
752	756	give	give	VB
757	761	rise	rise	NN
762	764	to	to	TO
765	766	a	a	DT
767	777	persistent	persistent	JJ
778	785	nuclear	nuclear	JJ
786	798	accumulation	accumulation	NN
799	801	of	of	IN
802	806	RelB	RelB	NNP
807	810	and	and	CC
811	816	c-Rel	c-rel	NN
816	817	,	,	,
818	825	whereas	whereas	IN
826	833	nuclear	nuclear	JJ
834	839	c-Rel	c-rel	NN
839	840	,	,	,
841	844	but	but	CC
845	848	not	not	RB
849	853	RelB	RelB	NNP
853	854	,	,	,
855	866	accumulated	accumulate	VBN
867	872	after	after	IN
873	874	B	B	NNP
875	879	cell	cell	NN
880	888	receptor	receptor	NN
889	900	stimulation	stimulation	NN
900	901	.	.	.

902	906	CD40	CD40	NNP
907	914	induced	induce	VBD
915	918	not	not	RB
919	923	only	only	RB
924	931	nuclear	nuclear	JJ
932	945	translocation	translocation	NN
946	949	but	but	CC
950	954	also	also	RB
955	957	de	de	FW
958	962	novo	novo	FW
963	972	synthesis	synthesis	NN
973	975	of	of	IN
976	980	RelB	RelB	NNP
981	984	RNA	RNA	NNP
985	988	and	and	CC
989	996	protein	protein	NN
996	997	.	.	.

998	1002	S107	S107	NNP
1003	1015	plasmacytoma	plasmacytoma	NN
1016	1021	cells	cell	NNS
1021	1022	,	,	,
1023	1028	which	which	WDT
1029	1036	express	express	VBP
1037	1041	CD40	cd40	NN
1042	1045	but	but	CC
1046	1049	are	be	VBP
1050	1059	defective	defective	JJ
1060	1063	for	for	IN
1064	1067	the	the	DT
1068	1075	nuclear	nuclear	JJ
1076	1086	appearance	appearance	NN
1087	1089	of	of	IN
1090	1107	p50/p65-NF-kappaB	p50/p65-NF-kappaB	NNP
1107	1108	,	,	,
1109	1111	do	do	VBP
1112	1115	not	not	RB
1116	1123	express	express	VB
1124	1128	RelB	RelB	NNP
1129	1134	after	after	IN
1135	1139	CD40	CD40	NNP
1140	1151	stimulation	stimulation	NN
1151	1152	.	.	.

1153	1155	In	in	IN
1156	1160	S107	s107	NN
1161	1166	cells	cell	NNS
1167	1173	stably	stably	RB
1174	1185	transfected	transfecte	VBN
1186	1190	with	with	IN
1191	1195	relB	relb	NN
1196	1201	genes	gene	NNS
1201	1202	,	,	,
1203	1214	stimulation	stimulation	NN
1215	1217	of	of	IN
1218	1225	nuclear	nuclear	JJ
1226	1230	RelB	RelB	NNP
1231	1244	translocation	translocation	NN
1245	1247	by	by	IN
1248	1252	CD40	CD40	NNP
1253	1256	was	be	VBD
1257	1265	observed	observe	VBN
1265	1266	.	.	.

1267	1272	These	these	DT
1273	1280	results	result	NNS
1281	1289	indicate	indicate	VBP
1290	1294	that	that	IN
1295	1306	stimulation	stimulation	NN
1307	1309	of	of	IN
1310	1314	CD40	CD40	NNP
1315	1324	signaling	signaling	NN
1325	1333	pathways	pathway	NNS
1334	1340	exerts	exert	VBZ
1341	1342	a	a	DT
1343	1355	long-lasting	long-lasting	JJ
1356	1367	stimulatory	stimulatory	JJ
1368	1374	effect	effect	NN
1375	1377	on	on	IN
1378	1382	both	both	CC
1383	1386	the	the	DT
1387	1400	transcription	transcription	NN
1401	1404	and	and	CC
1405	1412	nuclear	nuclear	JJ
1413	1426	translocation	translocation	NN
1427	1429	of	of	IN
1430	1434	RelB	RelB	NNP
1434	1435	.	.	.

1436	1441	Since	since	IN
1442	1445	LPS	LPS	NNP
1446	1449	and	and	CC
1450	1458	anti-IgM	anti-IgM	NNP
1459	1463	were	be	VBD
1464	1470	unable	unable	JJ
1471	1473	to	to	TO
1474	1482	activate	activate	VB
1483	1487	RelB	RelB	NNP
1487	1488	,	,	,
1489	1493	CD40	CD40	NNP
1494	1501	appears	appear	VBZ
1502	1504	to	to	TO
1505	1512	trigger	trigger	VB
1513	1514	a	a	DT
1515	1522	special	special	JJ
1523	1530	program	program	NN
1531	1533	of	of	IN
1534	1538	gene	gene	NN
1539	1549	expression	expression	NN
1550	1558	involved	involve	VBN
1559	1561	in	in	IN
1562	1565	the	the	DT
1566	1579	proliferation	proliferation	NN
1580	1586	and/or	and/or	CC
1587	1602	differentiation	differentiation	NN
1603	1605	of	of	IN
1606	1607	B	B	NNP
1608	1619	lymphocytes	lymphocyte	NNS
1619	1620	.	.	.