0	3	The	the	DT
4	7	p65	p65	NN
8	15	subunit	subunit	NN
16	18	of	of	IN
19	27	NF-kappa	NF-kappa	NNP
28	29	B	B	NNP
30	39	regulates	regulate	VBZ
40	41	I	i	NN
42	47	kappa	kappa	NN
48	49	B	b	NN
50	52	by	by	IN
53	56	two	two	CD
57	65	distinct	distinct	JJ
66	76	mechanisms	mechanism	NNS
76	77	.	.	.

79	92	Transcription	Transcription	NNP
93	99	factor	factor	NN
100	108	NF-kappa	NF-kappa	NNP
109	110	B	B	NNP
111	112	(	(	(
112	119	p50/p65	p50/p65	NN
119	120	)	)	)
121	123	is	be	VBZ
124	133	generally	generally	RB
134	143	localized	localized	JJ
144	146	to	to	TO
147	150	the	the	DT
151	160	cytoplasm	cytoplasm	NN
161	163	by	by	IN
164	167	its	its	PRP$
168	177	inhibitor	inhibitor	NN
178	179	I	i	NN
180	185	kappa	kappa	NN
186	188	B.	B.	NNP
189	201	Overproduced	Overproduced	NNP
202	203	I	i	NN
204	209	kappa	kappa	NN
210	211	B	B	NNP
211	212	,	,	,
213	217	free	free	JJ
218	222	from	from	IN
223	231	NF-kappa	NF-kappa	NNP
232	233	B	B	NNP
233	234	,	,	,
235	237	is	be	VBZ
238	245	rapidly	rapidly	RB
246	254	degraded	degrade	VBN
254	255	.	.	.

256	270	Overexpression	Overexpression	NNP
271	273	of	of	IN
274	277	p65	p65	NN
278	287	increases	increase	VBZ
288	298	endogenous	endogenous	JJ
299	300	I	i	NN
301	306	kappa	kappa	NN
307	308	B	B	NNP
309	316	protein	protein	NN
317	319	in	in	IN
320	324	both	both	CC
325	334	carcinoma	carcinoma	NN
335	338	and	and	CC
339	347	lymphoid	lymphoid	JJ
348	353	cells	cell	NNS
354	356	by	by	IN
357	360	two	two	CD
361	371	mechanisms	mechanism	NNS
371	372	:	:	:
373	380	protein	protein	NN
381	394	stabilization	stabilization	NN
395	398	and	and	CC
399	408	increased	increase	VBN
409	422	transcription	transcription	NN
423	425	of	of	IN
426	427	I	i	NN
428	433	kappa	kappa	NN
434	435	B	B	NNP
436	440	mRNA	mRNA	NNP
440	441	.	.	.

442	444	In	in	IN
445	453	contrast	contrast	NN
453	454	,	,	,
455	458	p65	p65	NN
459	464	delta	delta	NN
464	465	,	,	,
466	467	a	a	DT
468	477	naturally	naturally	RB
478	487	occurring	occur	VBG
488	494	splice	splice	NN
495	502	variant	variant	NN
502	503	,	,	,
504	509	fails	fail	VBZ
510	512	to	to	TO
513	521	markedly	markedly	RB
522	529	augment	augment	VB
530	531	I	i	NN
532	537	kappa	kappa	NN
538	539	B	B	NNP
540	547	protein	protein	NN
548	554	levels	level	NNS
554	555	.	.	.

556	560	Both	both	CC
561	574	overexpressed	overexpressed	JJ
575	578	p65	p65	NN
579	582	and	and	CC
583	594	coexpressed	coexpresse	VBN
595	598	p50	p50	NN
599	602	are	be	VBP
603	614	cytoplasmic	cytoplasmic	JJ
614	615	,	,	,
616	623	whereas	whereas	IN
624	627	p65	p65	NN
628	633	delta	delta	NN
634	636	is	be	VBZ
637	643	partly	partly	RB
644	651	nuclear	nuclear	JJ
651	652	,	,	,
653	663	indicating	indicate	VBG
664	668	that	that	IN
669	672	the	the	DT
673	674	I	i	NN
675	680	kappa	kappa	NN
681	682	B	B	NNP
683	690	induced	induce	VBN
691	693	by	by	IN
694	697	p65	p65	NN
698	701	can	can	MD
702	710	maintain	maintain	VB
711	719	NF-kappa	NF-kappa	NNP
720	721	B	B	NNP
722	724	in	in	IN
725	728	the	the	DT
729	738	cytoplasm	cytoplasm	NN
738	739	.	.	.

740	744	Thus	thus	RB
744	745	,	,	,
746	749	p65	p65	NN
750	753	and	and	CC
754	755	I	i	NN
756	761	kappa	kappa	NN
762	763	B	B	NNP
764	767	are	be	VBP
768	774	linked	link	VBN
775	777	in	in	IN
778	780	an	an	DT
781	795	autoregulatory	autoregulatory	JJ
796	800	loop	loop	NN
800	801	,	,	,
802	810	ensuring	ensure	VBG
811	815	that	that	IN
816	824	NF-kappa	NF-kappa	NNP
825	826	B	B	NNP
827	829	is	be	VBZ
830	834	held	hold	VBN
835	837	in	in	IN
838	841	the	the	DT
842	851	cytoplasm	cytoplasm	NN
852	857	until	until	IN
858	863	cells	cell	NNS
864	867	are	be	VBP
868	880	specifically	specifically	RB
881	888	induced	induce	VBN
889	891	to	to	TO
892	903	translocate	translocate	VB
904	906	it	it	PRP
907	909	to	to	TO
910	913	the	the	DT
914	921	nucleus	nucleus	NN
921	922	.	.	.