0 8 Evidence evidence NN 9 12 for for IN 13 19 normal normal JJ 20 27 vitamin vitamin NN 28 29 D D NNP 30 38 receptor receptor NN 39 48 messenger messenger NN 49 60 ribonucleic ribonucleic JJ 61 65 acid acid NN 66 69 and and CC 70 78 genotype genotype NN 79 81 in in IN 82 92 absorptive absorptive JJ 93 107 hypercalciuria hypercalciuria NN 107 108 . . . 110 120 Absorptive absorptive JJ 121 135 hypercalciuria hypercalciuria NN 136 137 ( ( ( 137 138 a a DT 139 152 stone-forming stone-forming JJ 153 162 condition condition NN 162 163 ) ) ) 164 166 is be VBZ 167 180 characterized characterize VBN 181 183 by by IN 184 187 gut gut NN 188 203 hyperabsorption hyperabsorption NN 204 206 of of IN 207 214 calcium calcium NN 214 215 , , , 216 230 hypercalciuria hypercalciuria NN 230 231 , , , 232 235 and and CC 236 243 reduced reduce VBD 244 248 bone bone NN 249 256 density density NN 256 257 . . . 258 266 Inasmuch inasmuch RB 267 269 as as IN 270 275 these these DT 276 284 features feature NNS 285 294 implicate implicate VBP 295 303 enhanced enhance VBN 304 314 calcitriol calcitriol NN 315 321 action action NN 322 324 in in IN 325 328 gut gut NN 329 332 and and CC 333 337 bone bone NN 337 338 , , , 339 341 we we PRP 342 350 analyzed analyze VBD 351 354 the the DT 355 362 vitamin vitamin NN 363 364 D D NNP 365 373 receptor receptor NN 374 375 ( ( ( 375 378 VDR VDR NNP 378 379 ) ) ) 380 384 gene gene NN 385 387 to to TO 388 397 ascertain ascertain VB 398 405 whether whether IN 406 408 an an DT 409 420 abnormality abnormality NN 421 423 of of IN 424 428 this this DT 429 433 gene gene NN 434 439 marks mark VBZ 440 448 patients patient NNS 449 453 with with IN 454 464 intestinal intestinal JJ 465 480 hyperabsorption hyperabsorption NN 481 483 of of IN 484 491 calcium calcium NN 491 492 . . . 493 495 We we PRP 496 500 have have VBP 501 509 compared compare VBN 510 513 the the DT 514 523 frequency frequency NN 524 526 of of IN 527 528 a a DT 529 540 restriction restriction NN 541 549 fragment fragment NN 550 556 length length NN 557 569 polymorphism polymorphism NN 570 571 ( ( ( 571 574 Bsm Bsm NNP 575 576 I i CD 576 577 ) ) ) 578 588 associated associate VBN 589 593 with with IN 594 603 different different JJ 604 611 alleles allele NNS 612 614 of of IN 615 618 the the DT 619 622 VDR VDR NNP 623 627 gene gene NN 628 630 in in IN 631 632 a a DT 633 638 group group NN 639 641 of of IN 642 644 33 33 CD 645 649 well well RB 650 663 characterized characterize VBN 664 674 absorptive absorptive JJ 675 689 hypercalciuric hypercalciuric JJ 690 698 patients patient NNS 699 702 and and CC 703 704 a a DT 705 710 group group NN 711 713 of of IN 714 716 36 36 CD 717 723 normal normal JJ 724 729 race- race- NN 730 733 and and CC 734 745 age-matched age-matched JJ 746 753 control control NN 754 762 subjects subject NNS 762 763 . . . 764 769 There there EX 770 773 was be VBD 774 776 no no DT 777 787 difference difference NN 788 795 between between IN 796 799 the the DT 800 812 distribution distribution NN 813 815 of of IN 816 819 the the DT 820 823 VDR vdr NN 824 831 alleles allele NNS 832 834 in in IN 835 838 the the DT 839 846 patient patient NN 847 857 population population NN 858 862 when when WRB 863 871 compared compare VBN 872 876 with with IN 877 880 the the DT 881 887 normal normal JJ 888 898 population population NN 898 899 . . . 900 903 The the DT 904 910 coding cod VBG 911 917 region region NN 918 920 of of IN 921 924 VDR VDR NNP 925 934 messenger messenger NN 935 938 RNA RNA NNP 939 942 was be VBD 943 947 also also RB 948 954 normal normal JJ 954 955 , , , 956 958 as as IN 959 969 determined determine VBN 970 972 by by IN 973 977 both both CC 978 981 DNA DNA NNP 982 990 sequence sequence NN 991 999 analysis analysis NN 1000 1003 and and CC 1004 1012 chemical chemical NN 1013 1021 mismatch mismatch NN 1022 1030 cleavage cleavage NN 1031 1039 analysis analysis NN 1040 1042 of of IN 1043 1047 copy copy NN 1048 1051 DNA dna NN 1052 1056 from from IN 1057 1059 11 11 CD 1060 1065 index index NN 1066 1076 absorptive absorptive JJ 1077 1091 hypercalciuric hypercalciuric JJ 1092 1100 patients patient NNS 1100 1101 . . . 1102 1104 On on IN 1105 1108 the the DT 1109 1114 basis basis NN 1115 1117 of of IN 1118 1123 these these DT 1124 1131 results result NNS 1131 1132 , , , 1133 1135 we we PRP 1136 1143 propose propose VBP 1144 1148 that that IN 1149 1152 the the DT 1153 1161 enhanced enhance VBN 1162 1172 intestinal intestinal JJ 1173 1180 calcium calcium NN 1181 1191 absorption absorption NN 1192 1202 invariably invariably RB 1203 1207 seen see VBN 1208 1210 in in IN 1211 1221 absorptive absorptive JJ 1222 1236 hypercalciuria hypercalciuria NN 1237 1240 and and CC 1241 1250 attendant attendant JJ 1251 1259 symptoms symptom NNS 1260 1262 of of IN 1263 1267 this this DT 1268 1276 disorder disorder NN 1277 1280 are be VBP 1281 1284 not not RB 1285 1297 attributable attributable JJ 1298 1300 to to TO 1301 1310 mutations mutation NNS 1311 1313 of of IN 1314 1317 the the DT 1318 1321 VDR vdr NN 1322 1325 and and CC 1326 1329 are be VBP 1330 1333 not not RB 1334 1340 linked link VBN 1341 1343 to to TO 1344 1345 a a DT 1346 1352 common common JJ 1353 1356 VDR vdr NN 1357 1365 genotype genotype NN 1365 1366 . . .