0 3 Bik Bik NNP 3 4 , , , 5 6 a a DT 7 12 novel novel JJ 13 27 death-inducing death-inducing JJ 28 35 protein protein NN 36 42 shares share VBZ 43 44 a a DT 45 53 distinct distinct JJ 54 62 sequence sequence NN 63 68 motif motif NN 69 73 with with IN 74 79 Bcl-2 bcl-2 NN 80 86 family family NN 87 95 proteins protein NNS 96 99 and and CC 100 109 interacts interact VBZ 110 114 with with IN 115 120 viral viral JJ 121 124 and and CC 125 133 cellular cellular JJ 134 152 survival-promoting survival-promoting JJ 153 161 proteins protein NNS 161 162 . . . 164 167 The the DT 168 186 survival-promoting survival-promoting JJ 187 195 activity activity NN 196 198 of of IN 199 202 the the DT 203 208 Bcl-2 bcl-2 NN 209 215 family family NN 216 218 of of IN 219 227 proteins protein NNS 228 235 appears appear VBZ 236 238 to to TO 239 241 be be VB 242 251 modulated modulate VBN 252 254 by by IN 255 267 interactions interaction NNS 268 275 between between IN 276 283 various various JJ 284 292 cellular cellular JJ 293 301 proteins protein NNS 301 302 . . . 303 305 We we PRP 306 310 have have VBP 311 321 identified identify VBN 322 323 a a DT 324 329 novel novel JJ 330 338 cellular cellular JJ 339 346 protein protein NN 346 347 , , , 348 351 Bik Bik NNP 351 352 , , , 353 357 that that WDT 358 367 interacts interact VBZ 368 372 with with IN 373 376 the the DT 377 385 cellular cellular JJ 386 404 survival-promoting survival-promoting JJ 405 413 proteins protein NNS 413 414 , , , 415 420 Bcl-2 Bcl-2 NNP 421 424 and and CC 425 431 Bcl-xL Bcl-xL NNP 431 432 , , , 433 435 as as RB 436 440 well well RB 441 443 as as IN 444 447 the the DT 448 453 viral viral JJ 454 472 survival-promoting survival-promoting JJ 473 481 proteins protein NNS 481 482 , , , 483 490 Epstein Epstein NNP 491 495 Barr Barr NNP 496 507 virus-BHRF1 virus-bhrf1 NN 508 511 and and CC 512 522 adenovirus adenovirus NN 523 529 E1B-19 e1b-19 NN 530 533 kDa kda NN 533 534 . . . 535 537 In in IN 538 547 transient transient JJ 548 560 transfection transfection NN 561 567 assays assay NNS 567 568 , , , 569 572 Bik Bik NNP 573 581 promotes promote VBZ 582 586 cell cell NN 587 592 death death NN 593 595 in in IN 596 597 a a DT 598 604 manner manner NN 605 612 similar similar JJ 613 615 to to TO 616 619 the the DT 620 635 death-promoting death-promoting JJ 636 643 members member NNS 644 646 of of IN 647 650 the the DT 651 656 Bcl-2 bcl-2 NN 657 663 family family NN 663 664 , , , 665 668 Bax Bax NNP 669 672 and and CC 673 676 Bak Bak NNP 676 677 . . . 678 682 This this DT 683 698 death-promoting death-promoting JJ 699 707 activity activity NN 708 710 of of IN 711 714 Bik Bik NNP 715 718 can can MD 719 721 be be VB 722 732 suppressed suppress VBN 733 735 by by IN 736 748 coexpression coexpression NN 749 751 of of IN 752 757 Bcl-2 bcl-2 NN 757 758 , , , 759 765 Bcl-XL Bcl-XL NNP 765 766 , , , 767 776 EBV-BHRF1 ebv-bhrf1 NN 777 780 and and CC 781 787 E1B-19 e1b-19 NN 788 791 kDa kda NN 792 800 proteins protein NNS 801 811 suggesting suggest VBG 812 816 that that IN 817 820 Bik Bik NNP 821 824 may may MD 825 827 be be VB 828 829 a a DT 830 836 common common JJ 837 843 target target NN 844 847 for for IN 848 852 both both CC 853 861 cellular cellular JJ 862 865 and and CC 866 871 viral viral JJ 872 886 anti-apoptotic anti-apoptotic JJ 887 895 proteins protein NNS 895 896 . . . 897 902 While while IN 903 906 Bik Bik NNP 907 911 does do VBZ 912 915 not not RB 916 920 show show VB 921 926 overt overt JJ 927 935 homology homology NN 936 938 to to TO 939 942 the the DT 943 946 BH1 bh1 NN 947 950 and and CC 951 954 BH2 bh2 NN 955 964 conserved conserve VBN 965 972 domains domain NNS 973 987 characteristic characteristic JJ 988 990 of of IN 991 994 the the DT 995 1000 Bcl-2 bcl-2 NN 1001 1007 family family NN 1007 1008 , , , 1009 1011 it it PRP 1012 1016 does do VBZ 1017 1022 share share VB 1023 1024 a a DT 1025 1026 9 9 CD 1027 1032 amino amino NN 1033 1037 acid acid NN 1038 1044 domain domain NN 1045 1046 ( ( ( 1046 1049 BH3 BH3 NNP 1049 1050 ) ) ) 1051 1055 with with IN 1056 1059 Bax Bax NNP 1060 1063 and and CC 1064 1067 Bak Bak NNP 1068 1073 which which WDT 1074 1077 may may MD 1078 1080 be be VB 1081 1082 a a DT 1083 1091 critical critical JJ 1092 1103 determinant determinant NN 1104 1107 for for IN 1108 1111 the the DT 1112 1127 death-promoting death-promoting JJ 1128 1136 activity activity NN 1137 1139 of of IN 1140 1145 these these DT 1146 1154 proteins protein NNS 1154 1155 . . .