0	3	SCL	SCL	NNP
4	7	and	and	CC
8	15	related	related	JJ
16	27	hemopoietic	hemopoietic	JJ
28	44	helix-loop-helix	helix-loop-helix	JJ
45	58	transcription	transcription	NN
59	66	factors	factor	NNS
66	67	.	.	.

69	72	The	the	DT
73	89	helix-loop-helix	helix-loop-helix	JJ
90	91	(	(	(
91	94	HLH	hlh	JJ
94	95	)	)	)
96	104	proteins	protein	NNS
105	108	are	be	VBP
109	110	a	a	DT
111	117	family	family	NN
118	120	of	of	IN
121	134	transcription	transcription	NN
135	142	factors	factor	NNS
143	147	that	that	WDT
148	155	include	include	VBP
156	164	proteins	protein	NNS
165	173	critical	critical	JJ
174	176	to	to	TO
177	192	differentiation	differentiation	NN
193	196	and	and	CC
197	208	development	development	NN
209	211	in	in	IN
212	219	species	specie	NNS
220	227	ranging	range	VBG
228	232	from	from	IN
233	239	plants	plant	NNS
240	242	to	to	TO
243	250	mammals	mammal	NNS
250	251	.	.	.

252	256	Five	five	CD
257	264	members	member	NNS
265	267	of	of	IN
268	272	this	this	DT
273	279	family	family	NN
280	281	(	(	(
281	284	MYC	MYC	NNP
284	285	,	,	,
286	289	SCL	SCL	NNP
289	290	,	,	,
291	296	TAL-2	TAL-2	NNP
296	297	,	,	,
298	303	LYL-1	LYL-1	NNP
304	307	and	and	CC
308	311	E2A	E2A	NNP
311	312	)	)	)
313	316	are	be	VBP
317	327	implicated	implicate	VBN
328	330	in	in	IN
331	340	oncogenic	oncogenic	JJ
341	347	events	event	NNS
348	350	in	in	IN
351	356	human	human	JJ
357	365	lymphoid	lymphoid	JJ
366	372	tumors	tumor	NNS
373	380	because	because	IN
381	383	of	of	IN
384	389	their	their	PRP$
390	400	consistent	consistent	JJ
401	412	involvement	involvement	NN
413	415	in	in	IN
416	427	chromosomal	chromosomal	JJ
428	442	translocations	translocation	NNS
442	443	.	.	.

444	452	Although	although	IN
453	462	activated	activate	VBN
463	465	in	in	IN
466	467	T	t	NN
468	472	cell	cell	NN
473	482	leukemias	leukemia	NNS
482	483	,	,	,
484	494	expression	expression	NN
495	497	of	of	IN
498	501	SCL	SCL	NNP
502	505	and	and	CC
506	511	LYL-1	LYL-1	NNP
512	514	is	be	VBZ
515	518	low	low	JJ
519	521	or	or	CC
522	534	undetectable	undetectable	JJ
535	537	in	in	IN
538	544	normal	normal	JJ
545	546	T	t	NN
547	551	cell	cell	NN
552	563	populations	population	NNS
563	564	.	.	.

565	568	SCL	SCL	NNP
569	571	is	be	VBZ
572	581	expressed	express	VBN
582	584	in	in	IN
585	594	erythroid	erythroid	JJ
594	595	,	,	,
596	609	megakaryocyte	megakaryocyte	NN
610	613	and	and	CC
614	618	mast	mast	NN
619	623	cell	cell	NN
624	635	populations	population	NNS
636	637	(	(	(
637	640	the	the	DT
641	645	same	same	JJ
646	650	cell	cell	NN
651	659	lineages	lineage	NNS
660	662	as	as	IN
663	669	GATA-1	gata-1	NN
669	670	,	,	,
671	672	a	a	DT
673	684	zinc-finger	zinc-finger	JJ
685	698	transcription	transcription	NN
699	705	factor	factor	NN
705	706	)	)	)
706	707	.	.	.

708	710	In	in	IN
711	719	addition	addition	NN
719	720	,	,	,
721	725	both	both	CC
726	729	SCL	SCL	NNP
730	733	and	and	CC
734	740	GATA-1	GATA-1	NNP
741	748	undergo	undergo	VBP
749	759	coordinate	coordinate	JJ
760	770	modulation	modulation	NN
771	777	during	during	IN
778	788	chemically	chemically	RB
789	796	induced	induce	VBN
797	806	erythroid	erythroid	JJ
807	822	differentiation	differentiation	NN
823	825	of	of	IN
826	831	mouse	mouse	NN
832	847	erythroleukemia	erythroleukemia	NN
848	853	cells	cell	NNS
854	857	and	and	CC
858	861	are	be	VBP
862	876	down-modulated	down-modulate	VBN
877	883	during	during	IN
884	891	myeloid	myeloid	JJ
892	907	differentiation	differentiation	NN
908	910	of	of	IN
911	916	human	human	JJ
917	921	K562	k562	NN
922	927	cells	cell	NNS
927	928	,	,	,
929	933	thus	thus	RB
934	942	implying	imply	VBG
943	944	a	a	DT
945	949	role	role	NN
950	953	for	for	IN
954	957	SCL	SCL	NNP
958	960	in	in	IN
961	970	erythroid	erythroid	JJ
971	986	differentiation	differentiation	NN
987	993	events	event	NNS
993	994	.	.	.

995	1002	However	however	RB
1002	1003	,	,	,
1004	1006	in	in	IN
1007	1015	contrast	contrast	NN
1016	1018	to	to	TO
1019	1025	GATA-1	gata-1	NN
1025	1026	,	,	,
1027	1030	SCL	SCL	NNP
1031	1033	is	be	VBZ
1034	1043	expressed	express	VBN
1044	1046	in	in	IN
1047	1050	the	the	DT
1051	1061	developing	develop	VBG
1062	1067	brain	brain	NN
1067	1068	.	.	.

1069	1076	Studies	study	NNS
1077	1079	of	of	IN
1080	1083	the	the	DT
1084	1092	function	function	NN
1093	1095	of	of	IN
1096	1099	SCL	SCL	NNP
1100	1107	suggest	suggest	VBP
1108	1110	it	it	PRP
1111	1113	is	be	VBZ
1114	1118	also	also	RB
1119	1128	important	important	JJ
1129	1131	in	in	IN
1132	1145	proliferation	proliferation	NN
1146	1149	and	and	CC
1150	1162	self-renewal	self-renewal	JJ
1163	1169	events	event	NNS
1170	1172	in	in	IN
1173	1182	erythroid	erythroid	JJ
1183	1188	cells	cell	NNS
1188	1189	.	.	.