0 8 Multiple multiple JJ 9 15 NF-ATc nf-atc NN 16 24 isoforms isoform NNS 25 29 with with IN 30 40 individual individual JJ 41 56 transcriptional transcriptional JJ 57 67 properties property NNS 68 71 are be VBP 72 83 synthesized synthesize VBN 84 86 in in IN 87 88 T t NN 89 100 lymphocytes lymphocyte NNS 100 101 . . . 103 106 The the DT 107 120 transcription transcription NN 121 127 factor factor NN 128 134 NF-ATc NF-ATc NNP 135 139 that that WDT 140 148 controls control VBZ 149 153 gene gene NN 154 164 expression expression NN 165 167 in in IN 168 169 T t NN 170 181 lymphocytes lymphocyte NNS 182 185 and and CC 186 195 embryonic embryonic JJ 196 203 cardiac cardiac JJ 204 209 cells cell NNS 210 212 is be VBZ 213 222 expressed express VBN 223 225 in in IN 226 231 three three CD 232 241 prominent prominent JJ 242 250 isoforms isoform NNS 250 251 . . . 252 256 This this DT 257 259 is be VBZ 260 263 due due JJ 264 266 to to TO 267 278 alternative alternative JJ 279 301 splice/polyadenylation splice/polyadenylation NN 302 308 events event NNS 309 313 that that WDT 314 318 lead lead VBP 319 321 to to TO 322 325 the the DT 326 337 predominant predominant JJ 338 347 synthesis synthesis NN 348 350 of of IN 351 354 two two CD 355 359 long long JJ 360 368 isoforms isoform NNS 369 371 in in IN 372 377 naive naive JJ 378 379 T t NN 380 385 cells cell NNS 386 389 and and CC 390 391 a a DT 392 399 shorter short JJR 400 406 NF-ATc NF-ATc NNP 407 414 isoform isoform NN 415 417 in in IN 418 426 effector effector NN 427 428 T t NN 429 434 cells cell NNS 434 435 . . . 436 443 Whereas whereas IN 444 447 the the DT 448 458 previously previously RB 459 468 described describe VBN 469 476 isoform isoform NN 477 485 NF-ATc/A NF-ATc/A NNP 486 494 contains contain VBZ 495 496 a a DT 497 507 relatively relatively RB 508 513 short short JJ 514 515 C C NNP 516 524 terminus terminus NNP 524 525 , , , 526 529 the the DT 530 536 longer long JJR 537 545 isoforms isoform NNS 545 546 , , , 547 548 B B NNP 549 552 and and CC 553 554 C C NNP 554 555 , , , 556 560 span span VBP 561 566 extra extra JJ 567 577 C-terminal c-terminal JJ 578 586 peptides peptide NNS 587 589 of of IN 590 593 128 128 CD 594 597 and and CC 598 601 246 246 CD 602 604 aa aa NN 604 605 , , , 606 618 respectively respectively RB 618 619 . . . 620 622 We we PRP 623 627 show show VBP 628 632 here here RB 633 637 that that IN 638 640 in in IN 641 649 addition addition NN 650 652 to to TO 653 656 the the DT 657 663 strong strong JJ 664 674 N-terminal n-terminal JJ 675 691 trans-activation trans-activation NN 692 698 domain domain NN 698 699 , , , 700 705 TAD-A TAD-A NNP 705 706 , , , 707 712 which which WDT 713 715 is be VBZ 716 722 common common JJ 723 725 to to TO 726 729 all all DT 730 735 three three CD 736 742 NF-ATc NF-ATc NNP 743 751 isoforms isoform NNS 751 752 , , , 753 761 NF-ATc/C NF-ATc/C NNP 762 770 contains contain VBZ 771 772 a a DT 773 779 second second JJ 780 796 trans-activation trans-activation NN 797 803 domain domain NN 803 804 , , , 805 810 TAD-B TAD-B NNP 810 811 , , , 812 814 in in IN 815 818 its its PRP$ 819 829 C-terminal c-terminal JJ 830 837 peptide peptide NN 837 838 . . . 839 846 Various various JJ 847 854 stimuli stimulus NNS 855 857 of of IN 858 859 T t NN 860 865 cells cell NNS 866 870 that that WDT 871 877 induce induce VBP 878 881 the the DT 882 890 activity activity NN 891 893 of of IN 894 899 TAD-A TAD-A NNP 900 904 also also RB 905 912 enhance enhance VBP 913 916 the the DT 917 925 activity activity NN 926 928 of of IN 929 934 TAD-B TAD-B NNP 934 935 , , , 936 939 but but CC 939 940 , , , 941 947 unlike unlike IN 948 953 TAD-A TAD-A NNP 953 954 , , , 955 960 TAD-B TAD-B NNP 961 968 remains remain VBZ 969 985 unphosphorylated unphosphorylated JJ 986 988 by by IN 989 996 protein protein NN 997 1001 from from IN 1002 1020 12-O-tetradecanoyl 12-O-tetradecanoyl NNP 1021 1031 12-phorbol 12-phorbol NN 1032 1053 13-acetate-stimulated 13-acetate-stimulated JJ 1054 1055 T t NN 1056 1061 cells cell NNS 1061 1062 . . . 1063 1066 The the DT 1067 1074 shorter short JJR 1075 1085 C-terminal c-terminal JJ 1086 1093 peptide peptide NN 1094 1096 of of IN 1097 1104 isoform isoform NN 1105 1113 NF-ATc/B NF-ATc/B NNP 1114 1120 exerts exert VBZ 1121 1122 a a DT 1123 1134 suppressive suppressive JJ 1135 1150 transcriptional transcriptional JJ 1151 1157 effect effect NN 1157 1158 . . . 1159 1164 These these DT 1165 1175 properties property NNS 1176 1178 of of IN 1179 1187 NF-ATc/B NF-ATc/B NNP 1188 1191 and and CC 1192 1194 -C -C NNP 1195 1200 might might MD 1201 1203 be be VB 1204 1206 of of IN 1207 1217 importance importance NN 1218 1221 for for IN 1222 1226 gene gene NN 1227 1237 regulation regulation NN 1238 1240 in in IN 1241 1246 naive naive JJ 1247 1248 T t NN 1249 1260 lymphocytes lymphocyte NNS 1261 1263 in in IN 1264 1269 which which WDT 1270 1278 NF-ATc/B NF-ATc/B NNP 1279 1282 and and CC 1283 1285 -C -C NNP 1286 1289 are be VBP 1290 1303 predominantly predominantly RB 1304 1315 synthesized synthesize VBN 1315 1316 . . .