0	8	Analysis	Analysis	NNP
9	11	of	of	IN
12	15	the	the	DT
16	26	modulation	modulation	NN
27	29	of	of	IN
30	45	transcriptional	transcriptional	JJ
46	54	activity	activity	NN
55	57	in	in	IN
58	70	myelopoiesis	myelopoiesis	NN
71	74	and	and	CC
75	89	leukemogenesis	leukemogenesis	NN
89	90	.	.	.

92	97	Acute	acute	JJ
98	105	myeloid	myeloid	JJ
106	114	leukemia	leukemia	NN
115	116	(	(	(
116	119	AML	AML	NNP
119	120	)	)	)
121	123	is	be	VBZ
124	129	still	still	RB
130	140	associated	associate	VBN
141	145	with	with	IN
146	147	a	a	DT
148	157	mortality	mortality	NN
158	160	of	of	IN
161	163	60	60	CD
164	166	to	to	TO
167	169	80	80	CD
169	170	%	%	NN
170	171	.	.	.

172	175	AML	AML	NNP
176	178	is	be	VBZ
179	192	characterized	characterize	VBN
193	195	by	by	IN
196	197	a	a	DT
198	203	block	block	NN
204	206	in	in	IN
207	214	myeloid	myeloid	JJ
215	230	differentiation	differentiation	NN
230	231	.	.	.

232	235	The	the	DT
236	249	transcription	transcription	NN
250	257	factors	factor	NNS
258	262	PU.1	PU.1	NNP
263	266	and	and	CC
267	277	C/EBPalpha	C/EBPalpha	NNP
278	281	are	be	VBP
282	293	responsible	responsible	JJ
294	297	for	for	IN
298	304	normal	normal	JJ
305	312	myeloid	myeloid	JJ
313	328	differentiation	differentiation	NN
329	333	from	from	IN
334	338	stem	stem	NN
339	344	cells	cell	NNS
345	347	to	to	TO
348	357	monocytes	monocyte	NNS
358	360	or	or	CC
361	373	granulocytes	granulocyte	NNS
373	374	.	.	.

375	377	In	in	IN
378	388	particular	particular	JJ
388	389	,	,	,
390	394	PU.1	PU.1	NNP
395	402	induces	induce	VBZ
403	413	expression	expression	NN
414	416	of	of	IN
417	420	the	the	DT
421	431	macrophage	macrophage	NN
432	450	colony-stimulating	colony-stimulating	JJ
451	457	factor	factor	NN
458	459	(	(	(
459	464	M-CSF	M-CSF	NNP
464	465	)	)	)
466	474	receptor	receptor	NN
475	478	and	and	CC
479	482	the	the	DT
483	494	development	development	NN
495	497	of	of	IN
498	507	monocytes	monocyte	NNS
507	508	,	,	,
509	516	whereas	whereas	IN
517	527	C/EBPalpha	C/EBPalpha	NNP
528	537	increases	increase	VBZ
538	541	the	the	DT
542	552	expression	expression	NN
553	555	of	of	IN
556	559	the	the	DT
560	571	granulocyte	granulocyte	NN
572	590	colony-stimulating	colony-stimulating	JJ
591	597	factor	factor	NN
598	599	(	(	(
599	604	G-CSF	G-CSF	NNP
604	605	)	)	)
606	614	receptor	receptor	NN
615	618	and	and	CC
619	624	leads	lead	VBZ
625	627	to	to	TO
628	634	mature	mature	JJ
635	647	granulocytes	granulocyte	NNS
647	648	.	.	.

649	651	In	in	IN
652	655	AML	AML	NNP
655	656	,	,	,
657	668	chromosomal	chromosomal	JJ
669	680	aberrations	aberration	NNS
681	687	result	result	VBP
688	690	in	in	IN
691	703	oncoproteins	oncoprotein	NNS
704	708	such	such	JJ
709	711	as	as	IN
712	720	AML1/ETO	AML1/ETO	NNP
720	721	,	,	,
722	734	PML/RARalpha	PML/RARalpha	NNP
734	735	,	,	,
736	738	or	or	CC
739	748	activated	activate	VBN
749	752	Ras	ras	NN
752	753	,	,	,
754	759	which	which	WDT
760	763	can	can	MD
764	774	deregulate	deregulate	VB
775	780	genes	gene	NNS
781	790	important	important	JJ
791	794	for	for	IN
795	801	normal	normal	JJ
802	814	myelopoiesis	myelopoiesis	NN
814	815	.	.	.

816	820	Thus	thus	RB
820	821	,	,	,
822	830	AML1/ETO	AML1/ETO	NNP
831	834	can	can	MD
835	839	bind	bind	VB
840	842	to	to	TO
843	846	the	the	DT
847	860	transcription	transcription	NN
861	867	factor	factor	NN
868	878	C/EBPalpha	C/EBPalpha	NNP
878	879	,	,	,
880	887	inhibit	inhibit	VBP
888	908	C/EBPalpha-dependent	c/ebpalpha-dependent	JJ
909	922	transcription	transcription	NN
922	923	,	,	,
924	927	and	and	CC
928	933	block	block	VB
934	946	granulocytic	granulocytic	JJ
947	962	differentiation	differentiation	NN
962	963	.	.	.

964	971	However	however	RB
971	972	,	,	,
973	981	AML1/ETO	AML1/ETO	NNP
982	985	can	can	MD
986	990	also	also	RB
991	1000	synergize	synergize	VB
1001	1005	with	with	IN
1006	1009	the	the	DT
1010	1023	transcription	transcription	NN
1024	1030	factor	factor	NN
1031	1035	AML1	aml1	NN
1036	1038	to	to	TO
1039	1046	enhance	enhance	VB
1047	1050	the	the	DT
1051	1059	activity	activity	NN
1060	1062	of	of	IN
1063	1066	the	the	DT
1067	1072	M-CSF	M-CSF	NNP
1073	1081	receptor	receptor	NN
1082	1090	promoter	promoter	NN
1090	1091	.	.	.

1092	1094	On	on	IN
1095	1098	the	the	DT
1099	1104	other	other	JJ
1105	1109	hand	hand	NN
1109	1110	,	,	,
1111	1114	the	the	DT
1115	1127	PML/RARalpha	PML/RARalpha	NNP
1128	1134	fusion	fusion	NN
1135	1142	protein	protein	NN
1143	1149	causes	cause	VBZ
1150	1165	transcriptional	transcriptional	JJ
1166	1176	repression	repression	NN
1177	1179	by	by	IN
1180	1190	recruiting	recruit	VBG
1191	1194	the	the	DT
1195	1202	nuclear	nuclear	JJ
1203	1214	corepressor	corepressor	NN
1215	1216	(	(	(
1216	1221	N-CoR	N-CoR	NNP
1221	1222	)	)	)
1223	1230	histone	histone	NN
1231	1242	deacetylase	deacetylase	NN
1243	1250	complex	complex	NN
1251	1253	to	to	TO
1254	1257	the	the	DT
1258	1261	DNA	dna	NN
1261	1262	,	,	,
1263	1268	which	which	WDT
1269	1276	results	result	VBZ
1277	1279	in	in	IN
1280	1289	decreased	decrease	VBN
1290	1297	histone	histone	NN
1298	1309	acetylation	acetylation	NN
1310	1313	and	and	CC
1314	1315	a	a	DT
1316	1326	repressive	repressive	JJ
1327	1336	chromatin	chromatin	NN
1337	1349	organization	organization	NN
1349	1350	.	.	.

1351	1355	Here	here	RB
1356	1358	we	we	PRP
1359	1367	describe	describe	VBP
1368	1375	methods	method	NNS
1376	1378	to	to	TO
1379	1390	investigate	investigate	VB
1391	1398	whether	whether	IN
1399	1402	and	and	CC
1403	1406	how	how	WRB
1407	1416	signaling	signaling	NN
1417	1425	agonists	agonist	NNS
1426	1432	induce	induce	VBP
1433	1440	myeloid	myeloid	JJ
1441	1456	differentiation	differentiation	NN
1457	1460	and	and	CC
1461	1464	how	how	WRB
1465	1477	oncoproteins	oncoprotein	NNS
1478	1483	might	might	MD
1484	1489	cause	cause	VB
1490	1493	AML	AML	NNP
1494	1496	by	by	IN
1497	1507	modulating	modulate	VBG
1508	1511	the	the	DT
1512	1520	activity	activity	NN
1521	1523	of	of	IN
1524	1537	transcription	transcription	NN
1538	1545	factors	factor	NNS
1546	1550	that	that	WDT
1551	1554	are	be	VBP
1555	1562	pivotal	pivotal	JJ
1563	1566	for	for	IN
1567	1573	normal	normal	JJ
1574	1581	myeloid	myeloid	JJ
1582	1593	development	development	NN
1593	1594	.	.	.

1595	1604	Copyright	Copyright	NNP
1605	1609	1999	1999	CD
1610	1618	Academic	Academic	NNP
1619	1624	Press	Press	NNP
1624	1625	.	.	.