0 14 Overproduction overproduction NN 15 17 of of IN 18 23 NFKB2 nfkb2 NN 24 25 ( ( ( 25 31 lyt-10 lyt-10 NN 31 32 ) ) ) 33 36 and and CC 37 42 c-Rel c-rel NN 42 43 : : : 44 45 a a DT 46 55 mechanism mechanism NN 56 59 for for IN 60 66 HTLV-I HTLV-I NNP 67 79 Tax-mediated tax-mediated JJ 80 96 trans-activation trans-activation NN 97 100 via via IN 101 104 the the DT 105 113 NF-kappa NF-kappa NNP 114 115 B B NNP 116 126 signalling signalling NN 127 134 pathway pathway NN 134 135 . . . 137 146 Molecular molecular JJ 146 147 , , , 148 159 biochemical biochemical JJ 160 163 and and CC 164 179 epidemiological epidemiological JJ 180 188 evidence evidence NN 189 198 implicate implicate VBP 199 205 HTLV-I HTLV-I NNP 206 208 as as IN 209 211 an an DT 212 221 etiologic etiologic JJ 222 227 agent agent NN 228 230 of of IN 231 236 adult adult JJ 237 238 T t NN 239 243 cell cell NN 244 252 leukemia leukemia NN 253 254 ( ( ( 254 257 ATL ATL NNP 257 258 ) ) ) 258 259 . . . 260 263 The the DT 264 267 Tax Tax NNP 268 275 protein protein NN 276 278 of of IN 279 285 HTLV-I HTLV-I NNP 285 286 , , , 287 288 a a DT 289 297 positive positive JJ 298 313 transcriptional transcriptional JJ 314 323 activator activator NN 324 326 of of IN 327 333 HTLV-I HTLV-I NNP 334 338 gene gene NN 339 349 expression expression NN 349 350 , , , 351 353 is be VBZ 354 355 a a DT 356 361 viral viral JJ 362 370 oncogene oncogene NN 371 375 that that WDT 376 380 also also RB 381 390 increases increase VBZ 391 404 transcription transcription NN 405 407 of of IN 408 416 cellular cellular JJ 417 422 genes gene NNS 423 432 including include VBG 433 439 GM-CSF GM-CSF NNP 439 440 , , , 441 446 IL-2R IL-2R NNP 447 452 alpha alpha NN 453 456 and and CC 457 461 IL-2 il-2 NN 461 462 . . . 463 466 One one CD 467 469 of of IN 470 473 the the DT 474 482 cellular cellular JJ 483 490 targets target NNS 491 493 of of IN 494 497 the the DT 498 514 trans-activating trans-activating JJ 515 522 effects effect NNS 523 525 of of IN 526 529 Tax Tax NNP 530 532 is be VBZ 533 536 the the DT 537 545 NF-kappa NF-kappa NNP 546 551 B/Rel B/Rel NNP 552 558 family family NN 559 561 of of IN 562 575 transcription transcription NN 576 583 factors factor NNS 583 584 , , , 585 596 pleiotropic pleiotropic JJ 597 607 regulators regulator NNS 608 610 of of IN 611 627 immunoregulatory immunoregulatory JJ 627 628 , , , 629 637 cytokine cytokine NN 638 641 and and CC 642 647 viral viral JJ 648 652 gene gene NN 653 663 expression expression NN 663 664 . . . 665 667 In in IN 668 672 this this DT 673 679 report report NN 679 680 , , , 681 683 we we PRP 684 695 demonstrate demonstrate VBP 696 700 that that IN 701 706 NFKB2 nfkb2 NN 707 708 ( ( ( 708 714 lyt-10 lyt-10 NN 714 715 ) ) ) 716 719 and and CC 720 725 c-Rel c-rel NN 726 729 are be VBP 730 743 overexpressed overexpresse VBN 744 746 in in IN 747 753 HTLV-I HTLV-I NNP 754 762 infected infected JJ 763 766 and and CC 767 781 Tax-expressing tax-expressing JJ 782 787 cells cell NNS 788 791 and and CC 791 792 , , , 793 801 together together RB 801 802 , , , 803 810 account account VBP 811 814 for for IN 815 818 the the DT 819 827 majority majority NN 828 830 of of IN 831 834 the the DT 835 847 constitutive constitutive JJ 848 856 NF-kappa NF-kappa NNP 857 858 B B NNP 859 866 binding binding NN 867 875 activity activity NN 876 878 in in IN 879 884 these these DT 885 890 cells cell NNS 891 897 before before IN 898 901 and and CC 902 907 after after IN 908 911 PMA PMA NNP 912 923 stimulation stimulation NN 923 924 . . . 925 929 Most most RBS 930 941 importantly importantly RB 941 942 , , , 943 945 we we PRP 946 950 show show VBP 951 952 a a DT 953 966 Tax-dependent tax-dependent JJ 967 978 correlation correlation NN 979 986 between between IN 987 997 expression expression NN 998 1000 of of IN 1001 1012 NFKB2(p100) nfkb2(p100) NN 1013 1016 and and CC 1017 1027 processing processing NN 1028 1030 to to TO 1031 1034 the the DT 1035 1038 DNA dna NN 1039 1046 binding binding NN 1047 1057 NFKB2(p52) nfkb2(p52) NN 1058 1062 form form NN 1062 1063 , , , 1064 1073 induction induction NN 1074 1076 of of IN 1077 1082 c-Rel c-rel NN 1082 1083 , , , 1084 1087 and and CC 1088 1104 trans-activation trans-activation NN 1105 1107 of of IN 1108 1116 NF-kappa NF-kappa NNP 1117 1127 B-mediated b-mediated JJ 1128 1132 gene gene NN 1133 1143 expression expression NN 1143 1144 . . . 1145 1156 Furthermore furthermore RB 1156 1157 , , , 1158 1161 the the DT 1162 1167 NFKB2 nfkb2 NN 1168 1177 precursor precursor NN 1178 1180 is be VBZ 1181 1191 physically physically RB 1192 1202 associated associate VBN 1203 1207 with with IN 1208 1213 c-Rel c-rel NN 1214 1217 and and CC 1218 1222 with with IN 1223 1226 Tax Tax NNP 1227 1229 in in IN 1230 1236 HTLV-I HTLV-I NNP 1237 1245 infected infected JJ 1246 1251 cells cell NNS 1251 1252 . . . 1253 1255 We we PRP 1256 1263 propose propose VBP 1264 1268 that that IN 1269 1274 NFKB2 nfkb2 NN 1275 1284 synthesis synthesis NN 1285 1288 and and CC 1289 1299 processing processing NN 1300 1306 allows allow VBZ 1307 1317 continuous continuous JJ 1318 1325 nuclear nuclear JJ 1326 1336 expression expression NN 1337 1339 of of IN 1340 1342 an an DT 1343 1352 otherwise otherwise RB 1353 1364 cytoplasmic cytoplasmic JJ 1365 1372 protein protein NN 1373 1376 and and CC 1376 1377 , , , 1378 1380 in in IN 1381 1392 conjunction conjunction NN 1393 1397 with with IN 1398 1412 overexpression overexpression NN 1413 1415 of of IN 1416 1421 c-Rel c-rel NN 1421 1422 , , , 1423 1428 NFKB2 nfkb2 NN 1429 1435 alters alter VBZ 1436 1439 the the DT 1440 1448 NF-kappa NF-kappa NNP 1449 1450 B B NNP 1451 1461 signalling signalling NN 1462 1469 pathway pathway NN 1470 1473 and and CC 1474 1485 contributes contribute VBZ 1486 1488 to to TO 1489 1497 leukemic leukemic JJ 1498 1512 transformation transformation NN 1513 1515 of of IN 1516 1517 T t NN 1518 1523 cells cell NNS 1524 1526 by by IN 1527 1533 HTLV-I HTLV-I NNP 1533 1534 . . .