0 8 NF-kappa NF-kappa NNP 9 10 B B NNP 11 19 controls control VBZ 20 30 expression expression NN 31 33 of of IN 34 43 inhibitor inhibitor NN 44 45 I i NN 46 51 kappa kappa NN 52 53 B B NNP 54 59 alpha alpha NN 59 60 : : : 61 69 evidence evidence NN 70 73 for for IN 74 76 an an DT 77 86 inducible inducible JJ 87 101 autoregulatory autoregulatory JJ 102 109 pathway pathway NN 109 110 . . . 112 115 The the DT 116 126 eukaryotic eukaryotic JJ 127 140 transcription transcription NN 141 147 factor factor NN 148 155 nuclear nuclear JJ 156 168 factor-kappa factor-kappa NN 169 170 B B NNP 171 172 ( ( ( 172 180 NF-kappa NF-kappa NNP 181 182 B B NNP 182 183 ) ) ) 184 196 participates participate VBZ 197 199 in in IN 200 204 many many JJ 205 210 parts part NNS 211 213 of of IN 214 217 the the DT 218 225 genetic genetic JJ 226 233 program program NN 234 243 mediating mediate VBG 244 245 T t NN 246 256 lymphocyte lymphocyte NN 257 267 activation activation NN 268 271 and and CC 272 278 growth growth NN 278 279 . . . 280 287 Nuclear nuclear JJ 288 298 expression expression NN 299 301 of of IN 302 310 NF-kappa NF-kappa NNP 311 312 B B NNP 313 319 occurs occur VBZ 320 325 after after IN 326 329 its its PRP$ 330 337 induced induce VBN 338 350 dissociation dissociation NN 351 355 from from IN 356 359 its its PRP$ 360 371 cytoplasmic cytoplasmic JJ 372 381 inhibitor inhibitor NN 382 383 I i NN 384 389 kappa kappa NN 390 391 B B NNP 392 397 alpha alpha NN 397 398 . . . 399 406 Phorbol Phorbol NNP 407 412 ester ester NN 413 416 and and CC 417 422 tumor tumor NN 423 431 necrosis necrosis NN 432 444 factor-alpha factor-alpha NN 445 454 induction induction NN 455 457 of of IN 458 465 nuclear nuclear JJ 466 474 NF-kappa NF-kappa NNP 475 476 B B NNP 477 479 is be VBZ 480 490 associated associate VBN 491 495 with with IN 496 500 both both CC 501 504 the the DT 505 516 degradation degradation NN 517 519 of of IN 520 529 performed perform VBN 530 531 I i NN 532 537 kappa kappa NN 538 539 B B NNP 540 545 alpha alpha NN 546 549 and and CC 550 553 the the DT 554 564 activation activation NN 565 567 of of IN 568 569 I i NN 570 575 kappa kappa NN 576 577 B B NNP 578 583 alpha alpha NN 584 588 gene gene NN 589 599 expression expression NN 599 600 . . . 601 613 Transfection transfection NN 614 621 studies study NNS 622 630 indicate indicate VBP 631 635 that that IN 636 639 the the DT 640 641 I i NN 642 647 kappa kappa NN 648 649 B B NNP 650 655 alpha alpha NN 656 660 gene gene NN 661 663 is be VBZ 664 676 specifically specifically RB 677 684 induced induce VBN 685 687 by by IN 688 691 the the DT 692 705 65-kilodalton 65-kilodalton JJ 706 721 transactivating transactivating NN 722 729 subunit subunit NN 730 732 of of IN 733 741 NF-kappa NF-kappa NNP 742 744 B. B. NNP 745 756 Association Association NNP 757 759 of of IN 760 763 the the DT 764 769 newly newly RB 770 781 synthesized synthesize VBN 782 783 I i NN 784 789 kappa kappa NN 790 791 B B NNP 792 797 alpha alpha NN 798 802 with with IN 803 806 p65 p65 NN 807 815 restores restore VBZ 816 829 intracellular intracellular JJ 830 840 inhibition inhibition NN 841 843 of of IN 844 852 NF-kappa NF-kappa NNP 853 854 B B NNP 855 858 DNA DNA NNP 859 866 binding binding NN 867 875 activity activity NN 876 879 and and CC 880 888 prolongs prolong VBZ 889 892 the the DT 893 901 survival survival NN 902 904 of of IN 905 909 this this DT 910 916 labile labile JJ 917 926 inhibitor inhibitor NN 926 927 . . . 928 936 Together together RB 936 937 , , , 938 943 these these DT 944 951 results result NNS 952 956 show show VBP 957 961 that that IN 962 970 NF-kappa NF-kappa NNP 971 972 B B NNP 973 981 controls control VBZ 982 985 the the DT 986 996 expression expression NN 997 999 of of IN 1000 1001 I i NN 1002 1007 kappa kappa NN 1008 1009 B B NNP 1010 1015 alpha alpha NN 1016 1018 by by IN 1019 1024 means mean NNS 1025 1027 of of IN 1028 1030 an an DT 1031 1040 inducible inducible JJ 1041 1055 autoregulatory autoregulatory JJ 1056 1063 pathway pathway NN 1063 1064 . . .