0 10 Inhibition Inhibition NNP 11 13 of of IN 14 22 NF-kappa NF-kappa NNP 23 24 B B NNP 25 33 activity activity NN 34 36 in in IN 37 42 human human JJ 43 44 T t NN 45 56 lymphocytes lymphocyte NNS 57 64 induces induce VBZ 65 82 caspase-dependent caspase-dependent JJ 83 92 apoptosis apoptosis NN 93 100 without without IN 101 111 detectable detectable JJ 112 122 activation activation NN 123 125 of of IN 126 135 caspase-1 caspase-1 NN 136 139 and and CC 140 142 -3 -3 CD 142 143 . . . 145 153 NF-kappa NF-kappa NNP 154 155 B B NNP 156 158 is be VBZ 159 167 involved involve VBN 168 170 in in IN 171 174 the the DT 175 190 transcriptional transcriptional JJ 191 198 control control NN 199 201 of of IN 202 209 various various JJ 210 215 genes gene NNS 216 220 that that WDT 221 224 act act VBP 225 227 as as IN 228 237 extrinsic extrinsic JJ 238 241 and and CC 242 251 intrinsic intrinsic JJ 252 260 survival survival NN 261 268 factors factor NNS 269 272 for for IN 273 274 T t NN 275 280 cells cell NNS 280 281 . . . 282 285 Our our PRP$ 286 294 findings finding NNS 295 299 show show VBP 300 304 that that IN 305 316 suppression suppression NN 317 319 of of IN 320 328 NF-kappa NF-kappa NNP 329 330 B B NNP 331 339 activity activity NN 340 344 with with IN 345 359 cell-permeable cell-permeable JJ 360 364 SN50 sn50 NN 365 372 peptide peptide NN 372 373 , , , 374 379 which which WDT 380 385 masks mask VBZ 386 389 the the DT 390 397 nuclear nuclear JJ 398 410 localization localization NN 411 419 sequence sequence NN 420 422 of of IN 423 431 NF-kappa NF-kappa NNP 432 434 B1 B1 NNP 435 441 dimers dimer NNS 442 445 and and CC 446 454 prevents prevent VBZ 455 460 their their PRP$ 461 468 nuclear nuclear JJ 469 481 localization localization NN 481 482 , , , 483 490 induces induce VBZ 491 500 apoptosis apoptosis NN 501 503 in in IN 504 511 resting rest VBG 512 518 normal normal JJ 519 524 human human JJ 525 528 PBL pbl NN 528 529 . . . 530 540 Inhibition Inhibition NNP 541 543 of of IN 544 552 NF-kappa NF-kappa NNP 553 554 B B NNP 555 563 resulted result VBD 564 566 in in IN 567 570 the the DT 571 586 externalization externalization NN 587 589 of of IN 590 608 phosphatidylserine phosphatidylserine NN 608 609 , , , 610 619 induction induction NN 620 622 of of IN 623 626 DNA dna NN 627 633 breaks break NNS 633 634 , , , 635 638 and and CC 639 652 morphological morphological JJ 653 660 changes change NNS 661 671 consistent consistent JJ 672 676 with with IN 677 686 apoptosis apoptosis NN 686 687 . . . 688 691 DNA DNA NNP 692 705 fragmentation fragmentation NN 706 709 was be VBD 710 721 efficiently efficiently RB 722 729 blocked block VBN 730 732 by by IN 733 736 the the DT 737 744 caspase caspase NN 745 754 inhibitor inhibitor NN 755 764 Z-VAD-fmk Z-VAD-fmk NNP 765 768 and and CC 769 778 partially partially RB 779 786 blocked block VBN 787 789 by by IN 790 801 Ac-DEVD-fmk Ac-DEVD-fmk NNP 801 802 , , , 803 813 suggesting suggest VBG 814 818 that that IN 819 832 SN50-mediated sn50-mediated JJ 833 842 apoptosis apoptosis NN 843 845 is be VBZ 846 863 caspase-dependent caspase-dependent JJ 863 864 . . . 865 878 Interestingly interestingly RB 878 879 , , , 880 889 apoptosis apoptosis NN 890 897 induced induce VBN 898 900 by by IN 901 909 NF-kappa NF-kappa NNP 910 911 B B NNP 912 923 suppression suppression NN 923 924 , , , 925 927 in in IN 928 936 contrast contrast NN 937 939 to to TO 940 944 that that DT 945 952 induced induce VBN 953 955 by by IN 956 960 TPEN TPEN NNP 961 962 ( ( ( 962 980 N,N,N’,N’-tetrakis N,N,N',N'-tetrakis NNP 981 982 [ [ ( 982 1013 2-pyridylmethyl]ethylenediamine 2-pyridylmethyl]ethylenediamine NN 1013 1014 ) ) ) 1015 1017 or or CC 1018 1025 soluble soluble JJ 1026 1029 Fas fas NN 1030 1036 ligand ligand NN 1037 1038 ( ( ( 1038 1042 CD95 CD95 NNP 1042 1043 ) ) ) 1043 1044 , , , 1045 1048 was be VBD 1049 1057 observed observe VBN 1058 1060 in in IN 1061 1064 the the DT 1065 1072 absence absence NN 1073 1075 of of IN 1076 1082 active active JJ 1083 1088 death death NN 1089 1097 effector effector NN 1098 1107 proteases protease NNS 1108 1122 caspase-1-like caspase-1-like JJ 1123 1124 ( ( ( 1124 1128 IL-1 il-1 NN 1129 1139 converting convert VBG 1140 1146 enzyme enzyme NN 1146 1147 ) ) ) 1147 1148 , , , 1149 1163 caspase-3-like caspase-3-like JJ 1164 1165 ( ( ( 1165 1183 CPP32/Yama/apopain CPP32/Yama/apopain NNP 1183 1184 ) ) ) 1184 1185 , , , 1186 1189 and and CC 1190 1204 caspase-6-like caspase-6-like JJ 1205 1208 and and CC 1209 1216 without without IN 1217 1225 cleavage cleavage NN 1226 1228 of of IN 1229 1238 caspase-3 caspase-3 NN 1239 1249 substrates substrate NNS 1250 1266 poly(ADP-ribose) poly(adp-ribose) NN 1267 1277 polymerase polymerase NN 1278 1281 and and CC 1282 1285 DNA dna NN 1286 1299 fragmentation fragmentation NN 1300 1309 factor-45 factor-45 NN 1309 1310 . . . 1311 1316 These these DT 1317 1325 findings finding NNS 1326 1333 suggest suggest VBP 1334 1340 either either CC 1341 1344 low low JJ 1345 1350 level level NN 1351 1353 of of IN 1354 1364 activation activation NN 1365 1367 is be VBZ 1368 1376 required require VBN 1377 1379 or or CC 1380 1384 that that IN 1385 1394 different different JJ 1395 1403 caspases caspas NNS 1404 1407 are be VBP 1408 1416 involved involve VBN 1416 1417 . . . 1418 1431 Preactivation Preactivation NNP 1432 1434 of of IN 1435 1436 T t NN 1437 1442 cells cell NNS 1443 1452 resulting result VBG 1453 1455 in in IN 1456 1464 NF-kappa NF-kappa NNP 1465 1466 B B NNP 1467 1474 nuclear nuclear JJ 1475 1488 translocation translocation NN 1489 1498 protected protect VBD 1499 1504 cells cell NNS 1505 1509 from from IN 1510 1522 SN50-induced sn50-induced JJ 1523 1532 apoptosis apoptosis NN 1532 1533 . . . 1534 1537 Our our PRP$ 1538 1546 findings finding NNS 1547 1558 demonstrate demonstrate VBP 1559 1561 an an DT 1562 1571 essential essential JJ 1572 1576 role role NN 1577 1579 of of IN 1580 1588 NF-kappa NF-kappa NNP 1589 1590 B B NNP 1591 1593 in in IN 1594 1602 survival survival NN 1603 1605 of of IN 1606 1611 naive naive JJ 1612 1615 PBL PBL NNP 1615 1616 . . .